A comparison of lipid variables as predictors of cardiovascular disease in the Asia Pacific Region

被引：122

作者：

Barzi, F ^{[1
]}

Patel, A ^{[1
]}

Woodward, M ^{[1
]}

Lawes, CMM ^{[1
]}

Ohkubo, T ^{[1
]}

Gu, D ^{[1
]}

Lam, TH ^{[1
]}

Ueshima, H ^{[1
]}

Gu, D ^{[1
]}

Lam, TH ^{[1
]}

Pan, W ^{[1
]}

Suh, I ^{[1
]}

Ueshima, H ^{[1
]}

Lawes, CMM ^{[1
]}

Rodgers, A ^{[1
]}

Woodward, M ^{[1
]}

Bennett, D ^{[1
]}

Parag, V ^{[1
]}

Xie, JX ^{[1
]}

Norton, R ^{[1
]}

Ameratunga, S ^{[1
]}

MacMahon, S ^{[1
]}

Whitlock, G ^{[1
]}

Knuiman, MW ^{[1
]}

Christensen, H ^{[1
]}

Zhou, J ^{[1
]}

Yu, XH ^{[1
]}

Gu, DF ^{[1
]}

Wu, XG ^{[1
]}

Tamakoshi, A ^{[1
]}

Pan, WH ^{[1
]}

Sritara, P ^{[1
]}

Wu, ZL ^{[1
]}

Chen, LQ ^{[1
]}

Shan, GL ^{[1
]}

Gu, DF ^{[1
]}

Duan, XF ^{[1
]}

MacMahon, S ^{[1
]}

Norton, R ^{[1
]}

Whitlock, G ^{[1
]}

Jackson, R ^{[1
]}

Li, YH ^{[1
]}

Lam, TH ^{[1
]}

Jiang, CQ ^{[1
]}

Fujishima, M ^{[1
]}

Kiyohara, Y ^{[1
]}

Iwamoto, H ^{[1
]}

Woo, J ^{[1
]}

Ho, SC ^{[1
]}

Hong, Z ^{[1
]}

机构：

[1] Univ Sydney, George Inst Int Hlth, Asia Pacific Cohort Studies Collaborat Secretaria, Camperdown, NSW 2050, Australia

来源：

ANNALS OF EPIDEMIOLOGY | 2005年 / 15卷 / 05期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

total cholesterol; LDL cholesterol; HDL cholesterol; non-HDL cholesterol; triglycerides; lipid ratios; cardiovascular heart disease; Asia-Pacific;

D O I：

10.1016/j.annepidem.2005.01.005

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

PURPOSE: Many guidelines advocate measurement of total or low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL), and triglycerides (TG) to determine treatment recommendations for preventing coronary heart disease (CHD) and cardiovascular disease (CVD). This analysis is a comparison of lipid variables as predictors of cardiovascular disease. METHODS: Hazard ratios for coronary and cardiovascular deaths by fourths of total cholesterol (TC), LDL, HDL, TG, non-HDL, TC/HDL, and TG/HDL values, and for a one standard deviation change in these variables, were derived in an individual participant data meta-analysis of 32 cohort studies conducted in the Asia-Pacific region. The predictive value of each lipid variable was assessed using the likelihood ratio statistic. RESULTS: Adjusting for confounders and regression dilution, each lipid variable had a positive (negative for HDL) log-linear association with fatal CHD and CVD. Individuals in the highest fourth of each lipid variable had approximately twice the risk of CHD compared with those with lowest levels. TG and HDL were each better predictors of CHD and CVD risk compared with TC alone, with test statistics similar to TC/HDL and TG/HDL ratios. Calculated LDL was a relatively poor predictor. CONCLUSIONS: While LDL reduction remains the main target of intervention for lipid-lowering, these data support the potential use of TG or lipid ratios for CHD risk prediction. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：405 / 413

页数：9

共 34 条

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