Management of fetal and neonatal alloimmune thrombocytopenia

被引:16
作者
Forestier, F
Hohlfeld, P [1 ]
机构
[1] CHU Vaudois, Dept Obstet Gynecol, CH-1011 Lausanne, Switzerland
[2] Inst Puericulture, Lab Biol Perinatale, F-75014 Paris, France
来源
BIOLOGY OF THE NEONATE | 1998年 / 74卷 / 06期
关键词
neonatal alloimmune thrombocytopenia; fetal blood sampling; in utero therapy; thrombocytopenia;
D O I
10.1159/000014060
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Fetal and neonatal thrombocytopenia can be induced by a maternal alloimmunization against fetal platelet antigens. Alloimmune thrombocytopenia occurs with an incidence of 1/1,000 livebirths and may present either with evidence of damage from a prenatal hemorrhage such as porencephaly or intrauterine death, or with active life-threatening bleeding during the neonatal period. It is due to the destruction of fetal platelets by alloantibodies reacting on specific antigenic sites. In Caucasians, the human platelet antigen 1a (HPA-1a) is the most frequently involved in alloimmune thrombocytopenias, accounting for 80-90% of the cases. Anti-HPA-Sb is responsible for a further 5-15% of the cases. This article reviews the clinical aspects, the biological diagnosis and the management, including prenatal sampling and maternal therapy.
引用
收藏
页码:395 / 401
页数:7
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