Highly pathogenic avian influenza (H5N1) in the commercial domestic ducks of South Korea

被引:47
作者
Kwon, YK [1 ]
Joh, SJ [1 ]
Kim, MC [1 ]
Sung, HW [1 ]
Lee, YJ [1 ]
Choi, JG [1 ]
Lee, EK [1 ]
Kim, JH [1 ]
机构
[1] Natl Vet Res & Quarantine Serv, Anyang 430824, South Korea
关键词
D O I
10.1080/03079450500181257
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
The present study reports the clinical, virological and pathological findings observed in a natural outbreak of highly pathogenic avian influenza in farmed commercial ducks. The ducks developed clinical signs, including mild respiratory distress, depression, mild diarrhoea, loss of appetite and increasing mortality (up to 12%). At necropsy, multifocal mottled necrosis was commonly found in the pancreas with splenomegaly, hepatomegaly, and swollen kidneys. Microscopically, there was necrotized pancreatitis and hepatitis, and lymphocytic meningoencephalitis and myocarditis. Influenza viral antigen was demonstrated in areas closely associated with histopathological lesion. Avian influenza virus was isolated from the caecal tonsil, faeces, and kidney of the domestic ducks. The isolated virus was identified as a highly pathogenic H5N1, with a haemagglutinin proteolytic cleavage site deduced amino acid sequence of... QREKRKKR/GLFGAIAG... In order to determine the pathogenicity of the isolate, eight 6-week-old specific pathogen free chickens were inoculated intravenously with the virus, and all birds died within 24 h after inoculation. This is the first report of an outbreak of highly pathogenic avian influenza with clinical signs in commercial domestic ducks in South Korea.
引用
收藏
页码:367 / 370
页数:4
相关论文
共 14 条
[1]   A review of avian influenza in different bird species [J].
Alexander, DJ .
VETERINARY MICROBIOLOGY, 2000, 74 (1-2) :3-13
[2]   ISOLATION OF AN INFLUENZA-A VIRUS FROM OSTRICHES (STRUTHIO-CAMELUS) [J].
ALLWRIGHT, DM ;
BURGER, WP ;
GEYER, A ;
TERBLANCHE, AW .
AVIAN PATHOLOGY, 1993, 22 (01) :59-65
[3]  
[Anonymous], 2003, DIS POULTRY
[4]   H7N1 avian influenza in Italy (1999 to 2000) in intensively reared chickens and turkeys [J].
Capua, I ;
Mutinelli, F ;
Marangon, S ;
Alexander, DJ .
AVIAN PATHOLOGY, 2000, 29 (06) :537-543
[5]   THE PERPETUATION OF ORTHOMYXOVIRUSES AND PARAMYXOVIRUSES IN CANADIAN WATERFOWL [J].
HINSHAW, VS ;
WEBSTER, RG ;
TURNER, B .
CANADIAN JOURNAL OF MICROBIOLOGY, 1980, 26 (05) :622-629
[6]   Characterization of highly pathogenic H5N1 avian influenza A viruses isolated from South Korea [J].
Lee, CW ;
Suarez, DL ;
Tumpey, TM ;
Sung, HW ;
Kwon, YK ;
Lee, YJ ;
Choi, JG ;
Joh, SJ ;
Kim, MC ;
Lee, EK ;
Park, JM ;
Lu, XH ;
Katz, JM ;
Spackman, E ;
Swayne, DE ;
Kim, JH .
JOURNAL OF VIROLOGY, 2005, 79 (06) :3692-3702
[7]   Experimental assessment of the pathogenicity of two avian influenza A H5 viruses in ostrich chicks (Struthio camelus) and chickens [J].
Manvell, RJ ;
Jorgensen, PH ;
Nielsen, OL ;
Alexander, DJ .
AVIAN PATHOLOGY, 1998, 27 (04) :400-404
[8]   Detection and subtyping (H5 and H7) of avian type A influenza virus by reverse transcription-PCR and PCR-ELISA [J].
Munch, M ;
Nielsen, LP ;
Handberg, KJ ;
Jorgensen, PH .
ARCHIVES OF VIROLOGY, 2001, 146 (01) :87-97
[9]  
Perkins LEL, 2002, AVIAN DIS, V46, P53, DOI 10.1637/0005-2086(2002)046[0053:POAHKO]2.0.CO
[10]  
2