Vasopressin: A potent autocrine/paracrine regulator of mammal adrenal functions.

被引:35
作者
Guillon, G [1 ]
Grazzini, E
Andrez, M
Breton, C
Trueba, M
Gal, CSL
Boccara, G
Derick, S
Chouinard, L
Gallo-Payet, N
机构
[1] CNRS, INSERM, U469, CCIPE, F-34094 Montpellier 05, France
[2] Sanofi Rech, Biochim Exploratoire, F-31036 Toulouse, France
[3] Univ Sherbrooke, Serv Endocrinol, Sherbrooke, PQ J1H 5N4, Canada
关键词
D O I
10.3109/07435809809032672
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The control of adrenal functions by locally secreted neuropeptides or neutotransmitters is of great physiological importance. Vasopressin (VP) is one of these autocrine/paracrine regulators. We demonstrated by RT-PCR and perifusion experiments that rat and human adrenal medulla expressed and released vasopressin under basal conditions and under stimulation by acetylcholine. Intra-adrenal concentrations of VP may be sufficient to activate adrenal VP receptors. In the cortex, only the Via receptor subtype has been detected. It triggered both steroid secretion and cortical growth. In the medulla, both Via and V1b receptor subtypes were expressed. V1b receptors were mainly present on chromaffin cells and stimulated catecholamine secretion. The role of the Via receptor remains unclear. Pathophysiological studies also revealed that human pheochromocytoma did not overexpress vasopressin receptors but might oversecrete vasopressin causing high plasma VP concentrations and elevated blood pressure.
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页码:703 / +
页数:9
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