Unresolved questions, changing definitions, and novel paradigms for defining endothelial progenitor cells

被引:352
作者
Ingram, DA
Caplice, NM
Yoder, MC
机构
[1] Indiana Univ, Sch Med, Herman B Wells Ctr Pediat Res, Dept Pediat, Indianapolis, IN 46202 USA
[2] Mayo Clin, Coll Med, Dept Med, Rochester, MN USA
[3] Mayo Clin, Coll Med, Dept Pharmacol, Rochester, MN USA
关键词
D O I
10.1182/blood-2005-04-1509
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The field of vascular biology has been stimulated by the concept that circulating endothelial progenitor cells (EPCs) may play a role in neoangiogenesis (postnatal vasculogenesis). One problem for the field has been the difficulty in accurately defining an EPC. Likewise, circulating endothelial cells (CECs) are not well defined. The lack of a detailed understanding of the proliferative potential of EPCs and CECs has contributed to the controversy in identifying these cells and understanding their biology in vitro or in vivo. A novel paradigm using proliferative potential as one defining aspect of EPC biology suggests that a hierarchy of EPCs exists in human blood and blood vessels. The potential implications of this view in relation to current EPC definitions are discussed.
引用
收藏
页码:1525 / 1531
页数:7
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