The habitual, diverse and surmountable obstacles to human immunology research

被引:46
作者
Hayday, Adrian C. [1 ,2 ]
Peakman, Mark [1 ,2 ]
机构
[1] Guys & St Thomas Hosp Fdn Trust, Natl Inst Hlth Res, Comprehens Biomed Res Ctr, London SE1 9RT, England
[2] Guys Hosp, Univ London Kings Coll, Sch Med, Peter Gorer Dept Immunobiol, London SE1 9RT, England
基金
英国医学研究理事会; 英国惠康基金;
关键词
D O I
10.1038/ni0608-575
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The need to translate basic research in the field of human immunology may be much more urgent, and the rewards potentially much greater, than is often acknowledged. Yet a commonly perceived coercion to undertake translational research may be unhelpful. Instead, we propose clear incentives for integrating key skill sets, together with achievable cultural adjustments in research and medicine that span training, recruitment and promotion.
引用
收藏
页码:575 / 580
页数:6
相关论文
共 9 条
  • [1] Establishing humanized mice using stem cells: maximizing the potential
    Bernard, D.
    Peakman, M.
    Hayday, A. C.
    [J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2008, 152 (03) : 406 - 414
  • [2] Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    Burton, Paul R.
    Clayton, David G.
    Cardon, Lon R.
    Craddock, Nick
    Deloukas, Panos
    Duncanson, Audrey
    Kwiatkowski, Dominic P.
    McCarthy, Mark I.
    Ouwehand, Willem H.
    Samani, Nilesh J.
    Todd, John A.
    Donnelly, Peter
    Barrett, Jeffrey C.
    Davison, Dan
    Easton, Doug
    Evans, David
    Leung, Hin-Tak
    Marchini, Jonathan L.
    Morris, Andrew P.
    Spencer, Chris C. A.
    Tobin, Martin D.
    Attwood, Antony P.
    Boorman, James P.
    Cant, Barbara
    Everson, Ursula
    Hussey, Judith M.
    Jolley, Jennifer D.
    Knight, Alexandra S.
    Koch, Kerstin
    Meech, Elizabeth
    Nutland, Sarah
    Prowse, Christopher V.
    Stevens, Helen E.
    Taylor, Niall C.
    Walters, Graham R.
    Walker, Neil M.
    Watkins, Nicholas A.
    Winzer, Thilo
    Jones, Richard W.
    McArdle, Wendy L.
    Ring, Susan M.
    Strachan, David P.
    Pembrey, Marcus
    Breen, Gerome
    St Clair, David
    Caesar, Sian
    Gordon-Smith, Katherine
    Jones, Lisa
    Fraser, Christine
    Green, Elain K.
    [J]. NATURE, 2007, 447 (7145) : 661 - 678
  • [3] Perspective - Primary immunodeficiencies: A field in its infancy
    Casanova, Jean-Laurent
    Abel, Laurent
    [J]. SCIENCE, 2007, 317 (5838) : 617 - 619
  • [4] Genetics of gene expression and its effect on disease
    Emilsson, Valur
    Thorleifsson, Gudmar
    Zhang, Bin
    Leonardson, Amy S.
    Zink, Florian
    Zhu, Jun
    Carlson, Sonia
    Helgason, Agnar
    Walters, G. Bragi
    Gunnarsdottir, Steinunn
    Mouy, Magali
    Steinthorsdottir, Valgerdur
    Eiriksdottir, Gudrun H.
    Bjornsdottir, Gyda
    Reynisdottir, Inga
    Gudbjartsson, Daniel
    Helgadottir, Anna
    Jonasdottir, Aslaug
    Jonasdottir, Adalbjorg
    Styrkarsdottir, Unnur
    Gretarsdottir, Solveig
    Magnusson, Kristinn P.
    Stefansson, Hreinn
    Fossdal, Ragnheidur
    Kristjansson, Kristleifur
    Gislason, Hjortur G.
    Stefansson, Tryggvi
    Leifsson, Bjorn G.
    Thorsteinsdottir, Unnur
    Lamb, John R.
    Gulcher, Jeffrey R.
    Reitman, Marc L.
    Kong, Augustine
    Schadt, Eric E.
    Stefansson, Kari
    [J]. NATURE, 2008, 452 (7186) : 423 - U2
  • [5] Opinion - Bias as a threat to the validity of cancer molecular-marker research
    Ransohoff, DF
    [J]. NATURE REVIEWS CANCER, 2005, 5 (02) : 142 - 149
  • [6] SCHWARTZ ND, 2008, INT HERALD TRIB 0325, P15
  • [7] London hospital launches infectious disease 'biobank'
    Towie, Narelle
    [J]. NATURE MEDICINE, 2007, 13 (06) : 653 - 653
  • [8] Warry P, 2006, INCREASING EC IMPACT
  • [9] The meaning of translational research and why it matters
    Woolf, Steven H.
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2008, 299 (02): : 211 - 213