Antibiotic resistance conferred by a conjugative plasmid and a class I integron in Vibrio cholerae O1 El Tor strains isolated in Albania and Italy

被引:81
作者
Falbo, V
Carattoli, A
Tosini, F
Pezzella, C
Dionisi, AM
Luzzi, I
机构
[1] Ist Super Sanita, Lab Ultrastruct, I-00161 Rome, Italy
[2] Ist Super Sanita, Lab Bacteriol & Med Mycol, I-00161 Rome, Italy
[3] Ist Super Sanita, Lab Cellular Biol, I-00161 Rome, Italy
关键词
D O I
10.1128/AAC.43.3.693
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Multidrug-resistant Vibrio cholerae O1 El Tor strains isolated during the 1994 outbreak of cholera in Albania and Italy were characterized for the molecular basis of antibiotic resistance. All strains were found to be resistant to tetracycline, streptomycin, spectinomycin, trimethoprim, sulfathiazole, and the vibriostatic compound O/129 (2,4-diamino-6,7-diisopropylteridine). Resistance genes were self-transferable by a conjugative plasmid of about 60 MDa, with the exception of spectinomycin resistance, which was conferred by the aadA1 gene cassette located in the bacterial chromosome within a class 1 integron. The resistance to trimethoprim and O/129 was conferred by the dfrA1 gene, which was present on the plasmid. Although the dfrA1 gene is known to be borne on an integron cassette, class 1, 2, or 3 intI genes were not detected as part of the plasmid DNA from the strains studied.
引用
收藏
页码:693 / 696
页数:4
相关论文
共 36 条
  • [1] CHARACTERIZATION OF PLASMIDS IN ENTEROBACTERIA
    ANDERSON, ES
    THRELFALL, EJ
    [J]. JOURNAL OF HYGIENE, 1974, 72 (03): : 471 - +
  • [2] A NOVEL INTEGRON-LIKE ELEMENT CARRYING THE METALLO-BETA-LACTAMASE GENE BLA(IMP)
    ARAKAWA, Y
    MURAKAMI, M
    SUZUKI, K
    ITO, H
    WACHAROTAYANKUN, R
    OHSUKA, S
    KATO, N
    OHTA, M
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (07) : 1612 - 1615
  • [3] SEQUENCE IDENTITY WITH TYPE-VIII AND ASSOCIATION WITH IS176 OF TYPE-IIIC DIHYDROFOLATE-REDUCTASE FROM SHIGELLA-SONNEI
    BARG, NL
    REGISTER, S
    THOMSON, C
    AMYES, S
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (01) : 112 - 116
  • [4] THE SALMONELLA-WIEN VIRULENCE PLASMID PZM3 CARRIES TN1935, A MULTIRESISTANCE TRANSPOSON CONTAINING A COMPOSITE IS1936-KANAMYCIN RESISTANCE ELEMENT
    COLONNA, B
    BERNARDINI, M
    MICHELI, G
    MAIMONE, F
    NICOLETTI, M
    CASALINO, M
    [J]. PLASMID, 1988, 20 (03) : 221 - 231
  • [5] VIBRIO-CHOLERAE IN THE HORN-OF-AFRICA - EPIDEMIOLOGY, PLASMIDS, TETRACYCLINE RESISTANCE GENE AMPLIFICATION, AND COMPARISON BETWEEN O1 AND NON-O1 STRAINS
    COPPO, A
    COLOMBO, M
    PAZZANI, C
    BRUNI, R
    MOHAMUD, KA
    OMAR, KH
    MASTRANDREA, S
    SALVIA, AM
    ROTIGLIANO, G
    MAIMONE, F
    [J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1995, 53 (04) : 351 - 359
  • [6] IDENTIFICATION AND CLASSIFICATION OF BACTERIAL PLASMIDS
    COUTURIER, M
    BEX, F
    BERGQUIST, PL
    MAAS, WK
    [J]. MICROBIOLOGICAL REVIEWS, 1988, 52 (03) : 375 - 395
  • [7] Datta N., 1979, PLASMIDS MED ENV COM, P3
  • [8] THE NUCLEOTIDE-SEQUENCE OF THE TRIMETHOPRIM-RESISTANT DIHYDROFOLATE-REDUCTASE GENE HARBORED BY TN7
    FLING, ME
    RICHARDS, C
    [J]. NUCLEIC ACIDS RESEARCH, 1983, 11 (15) : 5147 - 5158
  • [9] PLASMID-BORNE MULTIPLE-DRUG RESISTANCE IN VIBRIO-CHOLERAE SEROGROUP-01, BIOTYPE-EL TOR - EVIDENCE FOR A POINT-SOURCE OUTBREAK IN BANGLADESH
    GLASS, RI
    HUQ, MI
    LEE, JV
    THRELFALL, EJ
    KHAN, MR
    ALIM, ARMA
    ROWE, B
    GROSS, RJ
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1983, 147 (02) : 204 - 209
  • [10] TRANSPOSABLE RESISTANCE TO TRIMETHOPRIM AND 0/129 IN VIBRIO-CHOLERAE
    GOLDSTEIN, F
    GERBAUD, G
    COURVALIN, P
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1986, 17 (05) : 559 - 569