Cytoplasmic recognition of RNA

被引：47

作者：

Yoneyama, Mitsutoshi ^{[1
,2
,3
]}

Onmoto, Koji ^{[1
,2
]}

Fujita, Takashi ^{[1
,2
]}

机构：

[1] Kyoto Univ, Inst Virus Res, Mol Genet Lab, Dept Genet & Mol Biol, Kyoto 606, Japan

[2] Kyoto Univ, Grad Sch Biostudies, Mol Cell Biol Lab, Div Integrated Life Sci, Kyoto 606, Japan

[3] Japan Sci & Technol Agcy, PRESTO, Saitama, Japan

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2008年 / 60卷 / 07期

关键词：

interferon; RLR; dsRNA; viral RNA; self-non-self recognition;

D O I：

10.1016/j.addr.2007.12.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Non-self RNA appearing in a cell as a result of viral replication is detected by a cytoplasmic sensor called RIG-I-like receptor (RLR). RLR consists of RIG-I, MDA5, and LGP2, which are DExD/H helicases. Dornain structures of RLR for detecting non-self RNA and for relaying signals downstream have been elucidated. Different viruses produce structurally different RNA species and are sensed differentially by RLR molecules to initiate antiviral responses and subsequent antigen-specific adaptive immunity. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：841 / 846

页数：6

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