Host innate immune receptors and beyond: Making sense of microbial infections

被引：386

作者：

Ishii, Ken J. ^{[1
,2
,3
]}

Koyama, Shohei ^{[2
,3
]}

Nakagawa, Atsushi ^{[4
]}

Coban, Cevayir ^{[2
,3
]}

Akira, Shizuo ^{[2
,3
]}

机构：

[1] Osaka Univ, Dept Mol Protozool, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Dept Host Def, Res Inst Microbial Dis, Suita, Osaka 5650871, Japan

[3] Osaka Univ, Host Def Lab, WPI Immunol Frontier Res Ctr, Suita, Osaka 5650871, Japan

[4] Osaka Univ, Inst Prot Res, Lab Supramol Crystallog, Suita, Osaka 5650871, Japan

来源：

CELL HOST & MICROBE | 2008年 / 3卷 / 06期

关键词：

D O I：

10.1016/j.chom.2008.05.003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The complexity of the immune system mirrors its manifold mechanisms of host-microbe interactions. A relatively simplified view was posited after the identification of host innate immune receptors that their distinct mechanisms of sensing "microbial signatures" create unique molecular switches to trigger the immune system. Recently, more sophisticated and cooperative strategies for these receptors have been revealed during receptor-ligand interactions, trafficking, and intra- and intercellular signaling, in order to deal with a diverse range of microbes. Continued mapping of the complex networks of host-microbe interactions may improve our understanding of self/non-self discrimination in immunity and its intervention.

引用

页码：352 / 363

页数：12

共 123 条

[1] A conserved surface on Toll-like receptor 5 recognizes bacterial flagellin [J].

Andersen-Nissen, Erica ;

Smith, Kelly D. ;

Bonneau, Richard ;

Strong, Roland K. ;

Aderem, Alan .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (02) :393-403

[2] The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-β promoter [J].

Andrejeva, J ;

Childs, KS ;

Young, DF ;

Carlos, TS ;

Stock, N ;

Goodbourn, S ;

Randall, RE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (49) :17264-17269

[3] Cathepsin K-dependent Toll-like receptor 9 signaling revealed in experimental arthritis [J].

Asagiri, Masataka ;

Hirai, Toshitake ;

Kunigami, Toshihiro ;

Kamano, Shunya ;

Gober, Hans-Juergen ;

Okamoto, Kazuo ;

Nishikawa, Keizo ;

Latz, Eicke ;

Golenbock, Douglas T. ;

Aoki, Kazuhiro ;

Ohya, Keiichi ;

Imai, Yuuki ;

Morishita, Yasuyuki ;

Miyazono, Kohei ;

Kato, Shigeaki ;

Saftig, Paul ;

Takayanagi, Hiroshi .

SCIENCE, 2008, 319 (5863) :624-627

[4] The molecular structure of the TLR3 extracellular domain [J].

Bell, Jessica K. ;

Botos, Istvan ;

Hall, Pamela R. ;

Askins, Janine ;

Shiloach, Joseph ;

Davies, David R. ;

Segal, David M. .

JOURNAL OF ENDOTOXIN RESEARCH, 2006, 12 (06) :375-378

[5] Inferences, questions and possibilities in toll-like receptor signalling [J].

Beutler, B .

NATURE, 2004, 430 (6996) :257-263

[6] A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system [J].

Boneca, Ivo G. ;

Dussurget, Olivier ;

Cabanes, Didier ;

Nahori, Marie-Anne ;

Sousa, Sandra ;

Lecuit, Marc ;

Psylinakis, Emmanuel ;

Bouriotis, Vassilis ;

Hugot, Jean-Pierre ;

Giovannini, Marco ;

Coyle, Anthony ;

Bertin, John ;

Namane, Abdelkader ;

Rousselle, Jean-Claude ;

Cayet, Nadege ;

Prevost, Marie-Christine ;

Balloy, Viviane ;

Chignard, Michel ;

Philpottt, Dana J. ;

Cossart, Pascale ;

Girardin, Stephen E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (03) :997-1002

[7] The effect of NOD2 activation on TLR2-mediated cytokine responses is dependent on activation dose and NOD2 genotype [J].

Borm, M. E. A. ;

van Bodegraven, A. A. ;

Mulder, C. J. J. ;

Kraal, G. ;

Bouma, G. .

GENES AND IMMUNITY, 2008, 9 (03) :274-278

[8] The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling [J].

Brinkmann, Melanie M. ;

Spooner, Eric ;

Hoebe, Kasper ;

Beutler, Bruce ;

Ploegh, Hidde L. ;

Kim, You-Me .

JOURNAL OF CELL BIOLOGY, 2007, 177 (02) :265-275

[9] The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling [J].

Carty, Michael ;

Goodbody, Rory ;

Schroeder, Martina ;

Stack, Julianne ;

Moynagh, Paul N. ;

Bowie, Andrew G. .

NATURE IMMUNOLOGY, 2006, 7 (10) :1074-1081

[10] Herpes simplex virus encephalitis in human UNC-93B deficiency [J].

Casrouge, Armanda ;

Zhang, Shen-Ying ;

Eidenschenk, Celine ;

Jouanguy, Emmanuelle ;

Puel, Anne ;

Yang, Kun ;

Alcais, Alexandre ;

Picard, Capucine ;

Mahfoufi, Nora ;

Nicolas, Nathalie ;

Lorenzo, Lazaro ;

Plancoulaine, Sabine ;

Senechal, Brigitte ;

Geissmann, Frederic ;

Tabeta, Koichi ;

Hoebe, Kasper ;

Du, Xin ;

Miller, Richard L. ;

Heron, Benedicte ;

Mignot, Cyril ;

de Villemeur, Thierry Billette ;

Lebon, Pierre ;

Dulac, Olivier ;

Rozenberg, Flore ;

Beutler, Bruce ;

Tardieu, Marc ;

Abel, Laurent ;

Casanova, Jean-Laurent .

SCIENCE, 2006, 314 (5797) :308-312

← 1 2 3 4 5 6 7 8 9 10 →