Impact of Results of a Rapid Staphylococcus aureus Diagnostic Test on Prescribing of Antibiotics for Patients with Clustered Gram-Positive Cocci in Blood Cultures

被引:38
作者
Davies, Jane [1 ,2 ]
Gordon, Claire L. [1 ,2 ]
Tong, Steven Y. C. [1 ,3 ,4 ]
Baird, Robert W. [2 ]
Davis, Joshua S. [1 ,3 ,4 ]
机构
[1] Royal Darwin Hosp, Dept Infect Dis, Darwin, NT, Australia
[2] Royal Darwin Hosp, Dept Microbiol, Darwin, NT, Australia
[3] Menzies Sch Hlth Res, Darwin, NT, Australia
[4] Charles Darwin Univ, Darwin, NT 0909, Australia
基金
英国医学研究理事会;
关键词
GENEOHM STAPHSR ASSAY; REAL-TIME PCR; METHICILLIN-RESISTANT; XPERT MRSA/SA; BACTEREMIA; SPECIMENS; STRAINS;
D O I
10.1128/JCM.06773-11
中图分类号
Q93 [微生物学];
学科分类号
071005 [微生物学];
摘要
In tropical northern Australia, approximately 20% of Staphylococcus aureus bacteremia is caused by methicillin-resistant Staphylococcus aureus (MRSA). We prospectively evaluated the impact on clinician antibiotic prescribing of the results obtained from performing the GeneXpert MRSA/SA test on 151 positive blood cultures with clustered Gram-positive cocci. The GeneXpert result led to earlier appropriate prescription of vancomycin for 54% of patients with MRSA; 25% of patients avoided vancomycin, and 16% of patients had all antibiotics ceased.
引用
收藏
页码:2056 / 2058
页数:3
相关论文
共 12 条
[1]
An Antimicrobial Stewardship Program's Impact with Rapid Polymerase Chain Reaction Methicillin- Resistant Staphylococcus aureus/S. aureus Blood Culture Test in Patients with S. aureus Bacteremia [J].
Bauer, Karri A. ;
West, Jessica E. ;
Balada-Llasat, Joan-Miquel ;
Pancholi, Preeti ;
Stevenson, Kurt B. ;
Goff, Debra A. .
CLINICAL INFECTIOUS DISEASES, 2010, 51 (09) :1074-1080
[2]
Impact of Rapid Methicillin-Resistant Staphylococcus aureus Polymerase Chain Reaction Testing on Mortality and Cost Effectiveness in Hospitalized Patients with Bacteraemia A Decision Model [J].
Brown, Jack ;
Paladino, Joseph A. .
PHARMACOECONOMICS, 2010, 28 (07) :567-575
[3]
Community-associated meticillin-resistant Staphylococcus aureus [J].
DeLeo, Frank R. ;
Otto, Michael ;
Kreiswirth, Barry N. ;
Chambers, Henry F. .
LANCET, 2010, 375 (9725) :1557-1568
[4]
Evaluation of the BD GeneOhm StaphSR Assay for Detection of Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Isolates from Spiked Positive Blood Culture Bottles [J].
Groebner, Sabine ;
Dion, Mireille ;
Plante, Melanie ;
Kempf, Volkhard A. J. .
JOURNAL OF CLINICAL MICROBIOLOGY, 2009, 47 (06) :1689-1694
[5]
Evaluation of the Xpert™ MRSA/SA Blood Culture assay for the detection of Staphylococcus aureus including strains with reduced vancomycin susceptibility from blood culture specimens [J].
Kelley, Peter G. ;
Grabsch, Elizabeth A. ;
Farrell, Jenny ;
Xie, Shirley ;
Montgomery, Janet ;
Mayall, Barrie ;
Howden, Benjamin P. .
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2011, 70 (03) :404-407
[6]
Northern Territory Government Department of Health and Families, 2009, FEES CHARG MAN, P8
[7]
Identification of Methicillin-Resistant or Methicillin-Susceptible Staphylococcus aureus in Blood Cultures and Wound Swabs by GeneXpert [J].
Parta, M. ;
Goebel, M. ;
Matloobi, M. ;
Stager, C. ;
Musher, D. M. .
JOURNAL OF CLINICAL MICROBIOLOGY, 2009, 47 (05) :1609-1610
[8]
Accuracy and potential usefulness of triplex real-time PCR for improving antibiotic treatment of patients with blood cultures showing clustered gram-positive cocci on direct smears [J].
Ruimy, Raymond ;
Dos-Santos, Marie ;
Raskine, Laurent ;
Bert, Frederic ;
Masson, Rene ;
Elbaz, Sandrine ;
Bonnal, Christine ;
Lucet, Jean-Christophe ;
Lefort, Agnes ;
Fantin, Bruno ;
Wolff, Michel ;
Hornstein, Michele ;
Andremont, Antoine .
JOURNAL OF CLINICAL MICROBIOLOGY, 2008, 46 (06) :2045-2051
[9]
Interest of real-time PCR Xpert MRSA/SA on GeneXpert® DX System in the investigation of staphylococcal bacteremia [J].
Scanvic, A. ;
Courdavault, L. ;
Sollet, J-P ;
Le Turdu, F. .
PATHOLOGIE BIOLOGIE, 2011, 59 (02) :67-72
[10]
Clinical validation of the molecular BD GeneOhm StaphSR assay for direct detection of staphylococcus aureus and methicillin-resistant Staphylococcus aureus in positive blood cultures [J].
Stamper, Paul D. ;
Cai, Mian ;
Howard, Tracy ;
Speser, Sharon ;
Carroll, Karen C. .
JOURNAL OF CLINICAL MICROBIOLOGY, 2007, 45 (07) :2191-2196