Adaptive activation of thyroid hormone and energy expenditure

被引：111

作者：

Bianco, AC ^{[1
]}

Maia, AL ^{[1
]}

da Silva, WS ^{[1
]}

Christoffolete, MA ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp,Dept Med, Div Endocrinol Diabet & Hypertens,Thyroid Sect, Boston, MA 02115 USA

来源：

BIOSCIENCE REPORTS | 2005年 / 25卷 / 3-4期

关键词：

deiodinase; brown adipose tissue; skeletal muscle; uncoupling protein;

D O I：

10.1007/s10540-005-2885-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mechanisms by which thyroid hormone accelerates energy expenditure are poorly understood. In the brown adipose tissue (BAT), activation of thyroid hormone by type 2 iodothyronine deiodinase (D2) has been known to play a role in adaptive energy expenditure during cold exposure in human newborns and other small mammals. Although BAT is not present in significant amounts in normal adult humans, recent studies have found substantial amounts of D2 in skeletal muscle, a metabolically relevant tissue in humans. This article reviews current biological knowledge about D2 and adaptive T3 production and their roles in energy expenditure.

引用

收藏

页码：191 / 208

页数：18

相关论文

共 89 条

[1] Resting energy expenditure is sensitive to small dose changes in patients on chronic thyroid hormone replacement [J].

AlAdsani, H ;

Hoffer, LJ ;

Silva, JE .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1997, 82 (04) :1118-1125

[2] Hyperthyroidism increases the uncoupled ATPase activity and heat production by the sarcoplasmic reticulum Ca2+-ATPase [J].

Arruda, AP ;

Da-Silva, WS ;

Carvalho, DP ;

De Meis, L .

BIOCHEMICAL JOURNAL, 2003, 375 :753-760

[3] Up-regulation of UCP-2 gene expression by PPAR agonists in preadipose and adipose cells [J].

Aubert, J ;

Champigny, O ;

SaintMarc, P ;

Negrel, R ;

Collins, S ;

Ricquier, D ;

Ailhaud, G .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 238 (02) :606-611

[4] Human type 3 iodothyronine selenodeiodinase is located in the plasma membrane and undergoes rapid internalization to endosomes [J].

Baqui, M ;

Botero, D ;

Gereben, B ;

Curcio, C ;

Harney, JW ;

Salvatore, D ;

Sorimachi, K ;

Larsen, PR ;

Bianco, AC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (02) :1206-1211

[5] Distinct subcellular localization of transiently expressed types 1 and 2 iodothyronine deiodinases as determined by immunofluorescence confocal microscopy [J].

Baqui, MMA ;

Gereben, B ;

Harney, JW ;

Larsen, PR ;

Bianco, AC .

ENDOCRINOLOGY, 2000, 141 (11) :4309-4312

[6] Characterization of the 5′-flanking and 5′-untranslated regions of the cyclic adenosine 3′,5′-monophosphate-responsive human type 2 iodothyronine deiodinase gene [J].

Bartha, T ;

Kim, SW ;

Salvatore, D ;

Gereben, B ;

Tu, HM ;

Harney, JW ;

Rudas, P ;

Larsen, PR .

ENDOCRINOLOGY, 2000, 141 (01) :229-237

[7] COLD-EXPOSURE RAPIDLY INDUCES VIRTUAL SATURATION OF BROWN ADIPOSE-TISSUE NUCLEAR T3 RECEPTORS [J].

BIANCO, AC ;

SILVA, JE .

AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 255 (04) :E496-E503

[8] OPTIMAL RESPONSE OF KEY ENZYMES AND UNCOUPLING PROTEIN TO COLD IN BAT DEPENDS ON LOCAL T3-GENERATION [J].

BIANCO, AC ;

SILVA, JE .

AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 253 (03) :E255-E263

[9] ADENOSINE-3',5'-MONOPHOSPHATE AND THYROID-HORMONE CONTROL OF UNCOUPLING PROTEIN MESSENGER-RIBONUCLEIC-ACID IN FRESHLY DISPERSED BROWN ADIPOCYTES [J].

BIANCO, AC ;

KIEFFER, JD ;

SILVA, JE .

ENDOCRINOLOGY, 1992, 130 (05) :2625-2633

[10] NUCLEAR 3,5,3'-TRIIODOTHYRONINE (T-3) IN BROWN ADIPOSE-TISSUE - RECEPTOR OCCUPANCY AND SOURCES OF T-3 AS DETERMINED BY INVIVO TECHNIQUES [J].

BIANCO, AC ;

SILVA, JE .

ENDOCRINOLOGY, 1987, 120 (01) :55-62

← 1 2 3 4 5 6 7 8 9 →