Synthetic vaccines consisting of tumor-associated MUC1 glycopeptide antigens and bovine serum albumin

被引：81

作者：

Dziadek, S ^{[1
]}

Kowalczyk, D ^{[1
]}

Kunz, H ^{[1
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Inst Organ Chem, D-55128 Mainz, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 46期

关键词：

antigens; antitumor agents; carbohydrates; glycopeptides; synthetic vaccines;

D O I：

10.1002/anie.200501593

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

(Chemical Equation Presented) Sweet medicine: The mucin MUC1 is highly overexpressed on epithelial tumor cells. Glycopeptides 1 (from the repeating unit of MUC1) carrying various important sialylated tumor-associated carbohydrate antigens R were synthesized and coupled to bovine serum albumin (to generate anticancer vaccines) and to microtiter plates (to test the selectivity of the immune response). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7624 / 7630

页数：7

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