Translational control mechanisms modulate skeletal muscle gene expression during hypertrophy

被引：44

作者：

Bolster, DR ^{[1
]}

Kimball, SR ^{[1
]}

Jefferson, LS ^{[1
]}

机构：

[1] Penn State Univ, Coll Med, Dept Cellular & Mol Physiol, Hershey, PA 17033 USA

来源：

EXERCISE AND SPORT SCIENCES REVIEWS | 2003年 / 31卷 / 03期

关键词：

translation initiation; protein synthesis; resistance exercise; signal transduction; protein kinase B; mammalian target of rapamycin; S6K1; ACUTE RESISTANCE EXERCISE; PROTEIN-SYNTHESIS; MAMMALIAN TARGET; RAPAMYCIN; PATHWAY; PHOSPHORYLATION; INSULIN; GROWTH;

D O I：

10.1097/00003677-200307000-00002

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Understanding the basic mechanisms regulating skeletal muscle hypertrophy is essential to providing strategies for optimizing and maintaining skeletal muscle mass. This review focuses on the importance of mRNA translation in mediating acute increases in protein synthesis after resistance exercise as well as the anabolic response of muscle growth.

引用

页码：111 / 116

页数：6

共 15 条

[1] Phosphorylation of p70S6k correlates with increased skeletal muscle mass following resistance exercise
Baar, K
Esser, K
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 1999, 276 (01): : C120 - C127
[2] Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
Bodine, SC
Stitt, TN
Gonzalez, M
Kline, WO
Stover, GL
Bauerlein, R
Zlotchenko, E
Scrimgeour, A
Lawrence, JC
Glass, DJ
Yancopoulos, GD
[J]. NATURE CELL BIOLOGY, 2001, 3 (11) : 1014 - 1019
[3] Response of rat muscle to acute resistance exercise defined by transcriptional and translational profiling
Chen, YW
Nader, GA
Baar, KR
Fedele, MJ
Hoffman, EP
Esser, KA
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 2002, 545 (01): : 27 - 41
[4] CHANGES IN HUMAN MUSCLE PROTEIN-SYNTHESIS AFTER RESISTANCE EXERCISE
CHESLEY, A
MACDOUGALL, JD
TARNOPOLSKY, MA
ATKINSON, SA
SMITH, K
[J]. JOURNAL OF APPLIED PHYSIOLOGY, 1992, 73 (04) : 1383 - 1388
[5] Regulation of protein synthesis after acute resistance exercise in diabetic rats
Farrell, PA
Fedele, MJ
Vary, TC
Kimball, SR
Lang, CH
Jefferson, LS
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1999, 276 (04): : E721 - E727
[6] Fumagalli S, 2000, COLD SPRING HARBOR M, V39, P695
[7] Hershey JWB, 2000, COLD SPRING HARBOR M, V39, P33
[8] Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K
Kozma, SC
Thomas, G
[J]. BIOESSAYS, 2002, 24 (01) : 65 - 71
[9] A protein kinase B-dependent and rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specification
Pallafacchina, G
Calabria, E
Serrano, AL
Kalhovde, JM
Schiaffino, S
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (14) : 9213 - 9218
[10] Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load
Reynolds, TH
Bodine, SC
Lawrence, JC
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (20) : 17657 - 17662

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