Defensins in the immunology of bacterial infections

被引：117

作者：

Menendez, Alfredo ^{[1
]}

Finlay, B. Brett ^{[1
]}

机构：

[1] Univ British Columbia, Michael Smith Labs, Vancouver, BC V6T 1Z4, Canada

来源：

CURRENT OPINION IN IMMUNOLOGY | 2007年 / 19卷 / 04期

基金：

美国国家卫生研究院; 加拿大健康研究院; 加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/j.coi.2007.06.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Defensins are a component of the host response against bacterial infections. Multiple studies suggest a linked upregulation of (beta-defensins and pro-inflammatory cytokines expression in various tissues, as well as the possibility of mutual induction. Recent data demonstrate the importance of nucleotide-binding oligomerization proteins for the expression of defensins, and associate low levels of alpha-defensins expression by intestinal Paneth cells with susceptibility to Crohn's disease of the ileum. A novel anti-toxin activity has been identified for several alpha- and theta-defensins, expanding the repertoire of the antimicrobial functions of defensins. It has been shown that bacterial proteins can inactivate the action of defensins, and that pathogen type III secretion systems (T3SS) manipulate defensins expression via T3SS-mediated inhibition of the NF-kappa B pathway.

引用

页码：385 / 391

页数：7

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