Carbamazepine-2,2,2-trifluoroethanol (1/1)

被引:12
作者
Lohani, S
Zhang, YG
Chyall, LJ
Mougin-Andres, P
Muller, FX
Grant, DJW
机构
[1] Univ Minnesota, Coll Pharm, Dept Pharmaceut, Minneapolis, MN 55455 USA
[2] SSCI Inc, W Lafayette, IN 47906 USA
[3] GlaxoSmithKline, King Of Prussia, PA 19406 USA
来源
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS | 2005年 / 61卷
关键词
D O I
10.1107/S1600536805010299
中图分类号
O7 [晶体学];
学科分类号
0702 ; 070205 ; 0703 ; 080501 ;
摘要
The crystal structure of the title compound, C15H14N2O center dot-CF3CH2OH, which is the 2,2,2-trifluoroethanol (TFE) solvate of 5H-dibenzo[b,f]azepine-5-carboxamide (carbamazepine, CBZ), is reported. The asymmetric unit consists of two independent molecules of each component, CBZ and TFE.
引用
收藏
页码:O1310 / O1312
页数:3
相关论文
共 10 条
[1]   Drug therapy - Antiepileptic drugs [J].
Brodie, MJ ;
Dichter, MA .
NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (03) :168-175
[2]  
*BRUK AN XRAY INST, 2000, SADABS VERS 2 03
[3]  
*BRUK AN XRAY INST, 2003, SAINT PLUS VERS 6 45
[4]  
*BRUK AN XRAY INST, 2001, SMART VERS 5 054
[5]   New software for searching the Cambridge Structural Database and visualizing crystal structures [J].
Bruno, IJ ;
Cole, JC ;
Edgington, PR ;
Kessler, M ;
Macrae, CF ;
McCabe, P ;
Pearson, J ;
Taylor, R .
ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE CRYSTAL ENGINEERING AND MATERIALS, 2002, 58 :389-397
[6]   Rotational dynamics of nondipolar probes in ethanols: How does the strength of the solute-solvent hydrogen bond impede molecular rotation? [J].
Dutt, GB ;
Ghanty, TK .
JOURNAL OF CHEMICAL PHYSICS, 2003, 119 (09) :4768-4774
[8]   Crystal engineering of the composition of pharmaceutical phases:: Multiple-component crystalline solids involving carbamazepine [J].
Fleischman, SG ;
Kuduva, SS ;
McMahon, JA ;
Moulton, B ;
Walsh, RDB ;
Rodríguez-Hornedo, N ;
Zaworotko, MJ .
CRYSTAL GROWTH & DESIGN, 2003, 3 (06) :909-919
[9]   Comparison of the four anhydrous polymorphs of carbamazepine and the crystal structure of form I [J].
Grzesiak, AL ;
Lang, MD ;
Kim, K ;
Matzger, AJ .
JOURNAL OF PHARMACEUTICAL SCIENCES, 2003, 92 (11) :2260-2271
[10]   Form IV of carbamazepine [J].
Lang, MD ;
Kampf, JW ;
Matzger, AJ .
JOURNAL OF PHARMACEUTICAL SCIENCES, 2002, 91 (04) :1186-1190