Is it always unethical to use a placebo in a clinical trial?

被引：31

作者：

Stang, A

Hense, HW

Jöckel, KH

Turner, EH

Tramér, MR

机构：

[1] Department of Clinical Epidemiology, Inst. Med. Epidemiol., Biometr., I., Martin-Luther-Univ. Halle-Wittenberg

[2] Department of Clinical Epidemiology, Inst. Epidemiol. Social Med. Med. F., University of Münster

[3] Inst. Med. Info., Biometr., E., University Hospital of Essen

[4] Mood Disorders Program, Portland Veteran Aff. Medical Center

[5] Department of Psychiatry, Oregon Health and Science University, Portland, OR

[6] Dept. of Pharmacology and Physiology, Oregon Health and Science University, Portland, OR

[7] Geneva University Hospitals, Geneva

来源：

PLOS MEDICINE | 2005年 / 2卷 / 03期

关键词：

D O I：

10.1371/journal.pmed.0020072

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background to the debate: Placebos are used in trials to conceal whether a treatment is being given or not and hence to control for the psychosomatic effects of offering treatment. Placebo-controlled trials are controversial. Critics of such trials argue that if a proven effective therapy exists, a placebo should not be used. But proponents argue that placebo trials are still crucial to prove the efficacy and safety of many treatments.

引用

页码：177 / 180

页数：4

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