Serum dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEA-S) in Alzheimer's disease and in cerebrovascular dementia

被引：92

作者：

Yanase, T ^{[1
]}

Fukahori, M ^{[1
]}

Taniguchi, S ^{[1
]}

Nishi, Y ^{[1
]}

Sakai, Y ^{[1
]}

Takayanagi, R ^{[1
]}

Haji, M ^{[1
]}

Nawata, H ^{[1
]}

机构：

[1] MITATE HOSP,DEPT PSYCHIAT,FUKUOKA 81401,JAPAN

来源：

ENDOCRINE JOURNAL | 1996年 / 43卷 / 01期

关键词：

dehydroepiandrosterone (DHEA); DHEA-sulfate; Alzheimer's disease; cerebrovascular dementia;

D O I：

10.1507/endocrj.43.119

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A decreased concentration of dehydroepiandrosterone sulfate (DHEA-S) in patients with Alzheimer's disease (AD) has been reported but is still controversial. In the present study, serum concentrations of DHEA and DHEA-S were determined in 19 patients with AD, 21 patients with cerebrovascular dementia (CVD) and 45 age- and gender matched elderly control individuals from the Japanese community at large. Serum concentrations of DHEA among controls, patients with AD and patients with CVD did not significantly differ from one another. However, patients with AD and patients with CVD were found to have lower concentrations of serum DHEA-S and a lower DHEA-S/DHEA ratio compared to normal control individuals. No significant difference was observed in the concentration of serum DHEA-S or the DHEA-S/DHEA ratio between patients with AD and those with CVD. These results suggest that reduced concentrations of serum DHEA-S may not be unique to AD, but instead reflect a common phenomenon in dementing diseases. However, since serum concentration of DHEA in these patients remained unchanged, the significance of DHEA in dementia remains unclear.

引用

页码：119 / 123

页数：5

共 18 条

[1]

ALOM J, 1990, EUR NEUROL, V30, P207

[2] CEREBROSPINAL-FLUID SOMATOSTATIN AND NEUROPEPTIDE-Y - CONCENTRATIONS IN AGING AND IN DEMENTIA OF THE ALZHEIMER TYPE WITH AND WITHOUT EXTRAPYRAMIDAL SIGNS [J].