Aging and ischemia in gerbils impair spatial memory performance

被引：11

作者：

Schwartz, C

Wishart, TB

Ijaz, S

Shuaib, A

机构：

[1] Univ Saskatchewan, Dept Psychol, Saskatoon, SK S7N 5A5, Canada

[2] Univ Saskatchewan, Saskatchewan Stroke Res Ctr, Saskatoon, SK S7N 5A5, Canada

[3] Univ Saskatchewan, Dept Med, Saskatoon, SK S7N 5A5, Canada

来源：

BEHAVIORAL NEUROSCIENCE | 1998年 / 112卷 / 04期

关键词：

D O I：

10.1037/0735-7044.112.4.937

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Gerbils aged 3 months and 24+ months were subjected to 5 min of global forebrain ischemia and tested in a radial arm maze (1 trial/day, 50 days). Compared with age-matched, sham-operated controls, ischemic animals were impaired on measures of both working and reference memory. Aged animals were impaired on working memory, but not on reference memory, compared with their younger counterparts. Hippocampal CA1 and CA2 regions were significantly and comparably damaged in the 2 ischemic groups but were unaffected by aging. The results suggest that aging and ischemia have functionally similar effects on working memory, but the 2 processes differentially impact reference memory.

引用

页码：937 / 941

页数：5

共 32 条

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