Suppression of conditioned nicotine and sucrose seeking by the cannabinoid-1 receptor antagonist SR141716A

被引：77

作者：

De Vries, TJ ^{[1
]}

de Vries, W ^{[1
]}

Janssen, MCW ^{[1
]}

Schoffelmeer, ANM ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Neurosci Res Inst, Ctr Neurogenom & Cognit Res, Dept Med Pharmacol,VU Med Ctr, NL-1081 BT Amsterdam, Netherlands

来源：

BEHAVIOURAL BRAIN RESEARCH | 2005年 / 161卷 / 01期

关键词：

nicotine; self-administration; relapse; obesity; craving; conditioned reinforcement; drug seeking; cannabinoids; CB; 1; receptors; sucrose; natural reward seeking;

D O I：

10.1016/j.bbr.2005.02.021

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The present study shows that the selective cannabinoid CB1 receptor antagonist SR141716A attenuated responding for both nicotine- and sucrose-associated stimuli in a long-term extinction-reinstatement model. The results suggest that endocannabinoids play a general role in modulating cue reactivity or conditioned reinforcement following prolonged abstinence of both drug and natural reinforcers. In line with previous preclinical and recent clinical observations, our results provide a strong rationale for the use of CB1 antagonists in the treatment of addictive behaviors.

引用

页码：164 / 168

页数：5

共 24 条

[1] Endocannabinoid system modulates relapse to methamphetamine seeking: Possible mediation by the arachidonic acid cascade
Anggadiredja, K
Nakamichi, M
Hiranita, T
Tanaka, H
Shoyama, Y
Watanabe, S
Yamamoto, T
[J]. NEUROPSYCHOPHARMACOLOGY, 2004, 29 (08) : 1470 - 1478
[2] Circuitry for associative plasticity in the amygdala involves endocannabinoid signaling
Azad, SC
Monory, K
Marsicano, G
Cravatt, BF
Lutz, B
Zieglgänsberger, W
Rammes, G
[J]. JOURNAL OF NEUROSCIENCE, 2004, 24 (44) : 9953 - 9961
[3] Importance of nonpharmacological factors in nicotine self-administration
Caggiula, AR
Donny, EC
Chaudhri, N
Perkins, KA
Evans-Martin, FF
Sved, AF
[J]. PHYSIOLOGY & BEHAVIOR, 2002, 77 (4-5) : 683 - 687
[4] Lack of CB1 cannabinoid receptors modifies nicotine behavioural responses, but not nicotine abstinence
Castañé, A
Valjent, E
Ledent, C
Parmentier, M
Maldonado, R
Valverde, O
[J]. NEUROPHARMACOLOGY, 2002, 43 (05) : 857 - 867
[5] Behavioral effects of cannabinoid agents in animals
Chaperon, F
Thiébot, MH
[J]. CRITICAL REVIEWS IN NEUROBIOLOGY, 1999, 13 (03): : 243 - 281
[6] Childress A R, 1988, NIDA Res Monogr, V84, P25
[7] SR141716, a central cannabinoid (CB1) receptor antagonist, blocks the motivational and dopamine-releasing effects of nicotine in rats
Cohen, C
Perrault, G
Voltz, C
Steinberg, R
Soubrié, P
[J]. BEHAVIOURAL PHARMACOLOGY, 2002, 13 (5-6): : 451 - 463
[8] Cannabinoid CB1 receptor knockout mice fail to self-administer morphine but not other drugs of abuse
Cossu, G
Ledent, C
Fattore, L
Imperato, A
Böhme, GA
Parmentier, M
Fratta, W
[J]. BEHAVIOURAL BRAIN RESEARCH, 2001, 118 (01) : 61 - 65
[9] Functions of cannabinoid receptors in the hippocampus
Davies, SN
Pertwee, RG
Riedel, G
[J]. NEUROPHARMACOLOGY, 2002, 42 (08) : 993 - 1007
[10] Cannabinoid modulation of the reinforcing and motivational properties of heroin and heroin-associated cues in rats
De Vries, TJ
Homberg, JR
Binnekade, R
Raaso, H
Schoffelmeer, ANM
[J]. PSYCHOPHARMACOLOGY, 2003, 168 (1-2) : 164 - 169

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