Involvement of multiple functionally distinct cerebellar regions in visual discrimination: a human functional imaging study

被引:21
作者
Claeys, KG
Orban, GA
Dupont, P
Sunaert, S
Van Hecke, P
De Schutter, E
机构
[1] Univ Antwerp, Born Bunge Fdn, Lab Theoret Neurobiol, B-2610 Antwerp, Belgium
[2] Katholieke Univ Leuven, Sch Med, Neuro & Psychofysiol Lab, B-3000 Louvain, Belgium
[3] Univ Hosp Gasthuisberg, Dept Nucl Med, PET Ctr, B-3000 Louvain, Belgium
[4] Univ Hosp Gasthuisberg, Dept Radiol, MR Res Ctr, B-3000 Louvain, Belgium
关键词
D O I
10.1016/S1053-8119(03)00366-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We investigated the contribution of the human cerebellum to cerebral function during visual discrimination using PET and fMRI. The cognitive task was a successive discrimination of shades of brown with a parametric variation of the stimulus presentation rate and a constant task difficulty. The successive color discrimination task was contrasted to a dimming detection control task, with identical retinal input but with double the number of motor responses. Three sets of activated cerebellar and cerebral regions were observed: rate-dependent and rate-independent color discrimination networks and a motor-and-detection network. The rate-dependent color discrimination network included both an anterior and a posterior activation site in lobule-VI of the two lateral cerebellar hemispheres, whereas the rate-independent network involved a bilateral activation site in lateral Crus-I. Cerebellar sites of the motor-and-detection network were located in medial lobule-V bilaterally, in the vermis, and in posterior left Crus-I and right Crus-II. An additional fMRI study was performed to control for differences in motor output and response timing between the tasks. In this control study, the cerebellar activation sites of the rate-dependent and rate-independent color discrimination networks remained unaltered. The motor-and-detection network included cerebellar activations in posterior left Crus-I and right Crus-II, but none in lobule-V or the vermis. Thus, cerebellar activation sites of the motor-and-detection network could be subdivided into those related to a motor network and those belonging to a dimming detection network. We conclude that successive color discrimination activates multiple, functionally distinct cerebellar regions. (C) 2003 Elsevier Inc. All rights reserved.
引用
收藏
页码:840 / 854
页数:15
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