A generic approach for the catalytic reduction of nitriles

被引：135

作者：

Caddick, S ^{[1
]}

Judd, DB

Lewis, AKD

Reich, MT

Williams, MRV

机构：

[1] Univ Sussex, Chem Lab, Brighton BN1 9QJ, E Sussex, England

[2] GlaxoSmithKline, New Frontiers Sci Pk SCI, Harlow CM19 5AW, Essex, England

来源：

TETRAHEDRON | 2003年 / 59卷 / 29期

基金：

英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;

关键词：

catalytic; nickel boride; reduction; nitrites;

D O I：

10.1016/S0040-4020(03)00858-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The scope of nickel boride mediated reduction of nitriles has been extended further to allow the preparation of Boc protected amines via a mild catalytic process. It is noteworthy that the toxicity of this procedure is greatly reduced due to its catalytic nature in nickel(II) chloride used in combination with excess sodium borohydride. The protocol is marked by its resilience towards air and moisture and hence an easy and general practical protocol. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：5417 / 5423

页数：7

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