Updating p300: An integrative theory of P3a and P3b

被引：5604

作者：

Polich, John ^{[1
]}

机构：

[1] Scripps Res Inst, Mol & Integrat Neurosci Dept, Cognit Electphysiol Lab, La Jolla, CA 92037 USA

来源：

CLINICAL NEUROPHYSIOLOGY | 2007年 / 118卷 / 10期

关键词：

P300; P3a; P3b; ERP; attention memory; neuropsychology; neurotransmitters; inhibition; theory;

D O I：

10.1016/j.clinph.2007.04.019

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The empirical and theoretical development of the P300 event-related brain potential (ERP) is reviewed by considering factors that contribute to its amplitude, latency, and general characteristics. The neuropsychological origins of the P3a and P3b subcomponents are detailed, and how target/standard discrimination difficulty modulates scalp topography is discussed. The neural loci of P3a and P3b generation are outlined, and a cognitive model is proffered: P3a originates from stimulus-driven frontal attention mechanisms during task processing, whereas P3b originates from temporal-parietal activity associated with attention and appears related to subsequent memory processing. Neurotransmitter actions associating P3a to frontal/dopaminergic and P3b to parietal/norepinephrine pathways are highlighted. Neuroinhibition is suggested as an overarching theoretical mechanism for P300, which is elicited when stimulus detection engages memory operations. (C) 2007 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：2128 / 2148

页数：21

共 326 条

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