3-anilino-4-arylmaleimides: Potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3)

被引：156

作者：

Smith, DG ^{[1
]}

Buffet, M ^{[1
]}

Fenwick, AE ^{[1
]}

Haigh, D ^{[1
]}

Ife, RJ ^{[1
]}

Saunders, M ^{[1
]}

Slingsby, BP ^{[1
]}

Stacey, R ^{[1
]}

Ward, RW ^{[1
]}

机构：

[1] SmithKline Beecham Pharmaceut, Harlow CM19 5AW, Essex, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(00)00721-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Potent 3-anilino-4-arylmaleimide glycogen synthase kinase-3 (GSK-3) inhibitors have been prepared using automated array methodology. A number of these are highly selective, having little inhibitory potency against more than 20 other protein kinases. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：635 / 639

页数：5

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