Diastereoselective two-directional synthesis and cation transport ability of the central tristetrahydrofuranyl unit of meso polyether glabrescol as naturally occurring podand

被引：36

作者：

Morimoto, Y ^{[1
]}

Iwai, T ^{[1
]}

Yoshimura, T ^{[1
]}

Kinoshita, T ^{[1
]}

机构：

[1] Osaka City Univ, Grad Sch Sci, Dept Chem, Sumiyoshi Ku, Osaka 5588585, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 15期

关键词：

natural products; plants; cytotoxins; complexation;

D O I：

10.1016/S0960-894X(98)00347-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The diastereoselective synthesis of the central 2,5-linked tristetrahydrofuran (trisTHF) 6 of naturally occurring meso polyether, glabrescol (5), has been achieved in a two-directional manner by the vanadium(v)-catalyzed anti oxidative cyclizations of diol 14. The trisTHF podand 6 and its stereoisomeric analogs 7 and 8 exhibited outstanding cation transport abilities for physiologically important Na+ and K+. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2005 / 2010

页数：6

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