Structure-activity relationships of quinazoline derivatives:: Dual-acting compounds with inhibitory activities toward both TNF-α production and T cell proliferation

被引：17

作者：

Tobe, M ^{[1
]}

Isobe, Y ^{[1
]}

Tomizawa, H ^{[1
]}

Matsumoto, M ^{[1
]}

Obara, F ^{[1
]}

Nagasaki, T ^{[1
]}

Hayashi, H ^{[1
]}

机构：

[1] Japan Energy Corp, Pharmaceut & Biotechnol Lab, Toda, Saitama 3358502, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(00)00718-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We synthesized 4-chlorophenethylaminoquinazoline derivatives and evaluated their inhibitory activities toward both TNF-alpha production and T cell proliferation responses; Compound 2f, containing a piperazine ring at the C(7)-position of the quinazoline ring, exhibited more potent inhibitory activities toward both than the lead compound 1a. A smaller N-substituent in the piperazine ring was required for inhibition of TNF-alpha production. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：545 / 548

页数：4

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