Serum microRNAs as a novel class of biomarkers a comprehensive review of the literature

被引：144

作者：

Scholer, Nathalie ^{[1
]}

Langer, Christian ^{[2
]}

Dohner, Hartmut ^{[2
]}

Buske, Christian

Kuchenbauer, Florian ^{[2
]}

机构：

[1] Univ Ulm, Dept Internal Med 3, Inst Expt Canc Res, D-89081 Ulm, Germany

[2] Univ Hosp Ulm, Dept Internal Med 3, Ulm, Germany

来源：

EXPERIMENTAL HEMATOLOGY | 2010年 / 38卷 / 12期

关键词：

CIRCULATING MICRORNAS; EXPRESSION; CANCER; RNAS; DNA; DIAGNOSIS; LEUKEMIA; MARKERS; PLASMA;

D O I：

10.1016/j.exphem.2010.10.004

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Recently, expression patterns of microRNAs in body fluids underscored their potential as noninvasive biomarkers for various diseases Here we summarize the current works describing microRNAs in blood cells or serum as biomarkers and the applied methodologies of small RNA purification and detection Future challenges and the required research relating to optimization of working with microRNAs in serum will also be discussed (C) 2010 ISEH Society for Hematology and Stem Cells Published by Elsevier Inc

引用

页码：1126 / 1130

页数：5

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