Oxygen delivery and consumption during sepsis

被引:15
作者
Chittock, DR
Russell, JA
机构
[1] ST PAULS HOSP, DEPT MED, VANCOUVER, BC V6Z 1Y6, CANADA
[2] ST PAULS HOSP, DEPT CRIT CARE MED, VANCOUVER, BC V6Z 1Y6, CANADA
[3] ST PAULS HOSP, DEPT HLTH CARE & EPIDEMIOL, VANCOUVER, BC V6Z 1Y6, CANADA
[4] UNIV BRITISH COLUMBIA, FAC MED, DEPT MED, VANCOUVER, BC, CANADA
[5] UNIV BRITISH COLUMBIA, FAC MED, PROGRAM CRIT CARE MED, VANCOUVER, BC, CANADA
关键词
D O I
10.1016/S0272-5231(05)70313-0
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
This article discusses the oxygen consumption (Vo(2)) and delivery (Do(2)) relationship as it pertains to animal models of sepsis and human sepsis syndrome and septic shock. Pathologic dependence of Vo(2) on Do(2) is not present in resuscitated patients who have sepsis syndrome and septic shock. Defects in oxygen extraction and use at the individual organ level with maldistribution of blood flow probably do occur in sepsis; however, there is no clinical evidence that augmenting Do(2) to supernormal levels decreases organ dysfunction or mortality in sepsis. We need improved techniques to assess tissue hypoxia at the organ level, and we need to test therapies directed at correcting the maldistribution of blood flow and O-2 use defects of sepsis.
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收藏
页码:263 / +
页数:1
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