White matter microstructure in patients with obsessive-compulsive disorder

被引：66

作者：

Bora, Emre ^{[1
,2
]}

Harrison, Ben J.

Fornito, Alex ^{[2
,3
]}

Cocchi, Luca ^{[2
]}

Pujol, Jesus ^{[4
]}

Fontenelle, Leonardo F. ^{[5
]}

Velakoulis, Dennis ^{[2
]}

Pantelis, Christos ^{[2
]}

Yuecel, Murat ^{[2
,6
]}

机构：

[1] Univ Melbourne, Melbourne Neuropsychiat Ctr, Dept Psychiat, Melbourne, Vic 3053, Australia

[2] Melbourne Hlth, Melbourne, Vic, Australia

[3] Univ Cambridge, Dept Psychiat, Brain Mapping Unit, Cambridge CB2 1TN, England

[4] Ctr Radiol Computerizado Corp Sanitaria, Inst Alta Tecnol, Barcelona, Spain

[5] UFRJ, Anxiety & Depress Res Program, Inst Psychiat IPUB, Rio De Janeiro, Brazil

[6] Univ Melbourne, Ctr Youth Mental Hlth, Orygen Youth Hlth Res Ctr, Melbourne, Vic 3053, Australia

来源：

JOURNAL OF PSYCHIATRY & NEUROSCIENCE | 2011年 / 36卷 / 01期

基金：

瑞士国家科学基金会; 英国医学研究理事会; 澳大利亚研究理事会;

关键词：

DIFFUSION-TENSOR; CORPUS-CALLOSUM; RADIAL DIFFUSIVITY; VOXELWISE ANALYSIS; BRAIN; ABNORMALITIES; CONNECTIVITY;

D O I：

10.1503/jpn.100082

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Previous diffusion tensor imaging (DTI) studies in patients with obsessive-compulsive disorder (OCD) have reported inconsistent findings, and it is not known whether observed findings are related to abnormalities in axonal structure or myelination. Methods: In this DTI study, we investigated fractional anisotropy, as well as axial and radial diffusivity, in 21 patients with OCD and 29 healthy controls. Results: We found decreased fractional anisotropy in the body of the corpus callosum in the OCD group, which was underpinned by increased radial diffusivity. Limitations: The cross-sectional design was the main limitation. Conclusion: Our findings of increased radial diffusivity provide preliminary evidence for abnormal myelination in patients with OCD.

引用

页码：42 / 46

页数：5

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