Solid-phase synthesis of asymmetric cyanine dyes

被引：40

作者：

Isacsson, J

Westman, G

机构：

[1] Chalmers Univ Technol, Dept Mol Biotechnol, S-40530 Gothenburg, Sweden

[2] Diffchamb AB, S-42246 Hisings Backa, Sweden

[3] Chalmers Univ Technol, Dept Organ Chem, S-41296 Gothenburg, Sweden

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 18期

关键词：

cyanine dye; solid-phaser combinatorial; DNA; light-up probe;

D O I：

10.1016/S0040-4039(01)00365-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient solid-phase synthesis of asymmetric cyanine dyes is described. Combinatorial synthesis and spectroscopic analysis of four dyes was carried out. The yields are quantitative after 20 h, but the reaction can be halted earlier, since it is shown that the starting material does not disturb the fluorescence measurements in these binding studies. (C) 2001 Elsevier Science Ltd. All rights reserved.

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收藏

页码：3207 / 3210

页数：4

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