Palladium-catalyzed Negishi cross-coupling reactions of unactivated alkyl iodides, bromides, chlorides, and tosylates

被引：255

作者：

Zhou, JR ^{[1
]}

Fu, GC ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 41期

关键词：

D O I：

10.1021/ja0363258

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A single method (2% Pd-2(dba)(3)/8% PCyp(3)/NMI in THF/NMP at 80 degreesC; Cyp = cyclopentyl) achieves the cross-coupling of a range of beta-hydrogen-containing primary alkyl iodides, bromides, chlorides, and tosylates with an array of alkyl-, alkenyl-, and arylzinc halides. The process is compatible with a variety of functional groups, including esters, amides, imides, nitriles, and heterocycles.

引用

页码：12527 / 12530

页数：4

共 38 条

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