Novel design of a pentacyclic scaffold as structural mimic of saframycin A

被引：26

作者：

Ong, CW ^{[1
]}

Chang, YA

Wu, JY

Cheng, CC

机构：

[1] Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 804, Taiwan

[2] Chung Chou Inst Technol, Changhua 501, Taiwan

[3] Tamkang Univ, Dept Chem, Tamsui 25137, Taiwan

来源：

TETRAHEDRON | 2003年 / 59卷 / 41期

关键词：

5a; 12a-diazapentacene; saframycin model; DNA binding and scissioning;

D O I：

10.1016/j.tet.2003.08.036

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The design, synthesis and evaluation of a pentacyclic scaffold, CWO-324 to mimic saframycin A is described. CWO-324 is readily synthesized in five steps from 1,4-diacetyl-piperazine-2,5-dione and 2,5-dimethoxybenzaldehyde. CWO-324 was found to scission DNA, binds to bases 69-83(5'-GCAGTCAGG CACCGT-3') of Hind III/Rsa I from plasmid pBR322 DNA in a foot-printing study and possesses anti-tumor activity. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：8245 / 8249

页数：5

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