Ten years of genetics and genomics: what have we achieved and where are we heading?

被引：44

作者：

Heard, Edith ^{[1
]}

Tishkoff, Sarah ^{[2
,3
]}

Todd, John A. ^{[4
]}

Vidal, Marc ^{[5
,6
,7
]}

Wagner, Guenter P. ^{[8
]}

Wang, Jun ^{[9
,10
]}

Weigel, Detlef ^{[11
]}

Young, Richard ^{[12
]}

机构：

[1] Inst Curie, Mammalian Dev Epigenet Grp, INSERM, Unite Genet & Biol Dev,CNRS,UMR3215,U934, F-75248 Paris 05, France

[2] Univ Penn, Dept Genet, Sch Med, Philadelphia, PA 19104 USA

[3] Univ Penn, Dept Biol, Sch Med, Philadelphia, PA 19104 USA

[4] Univ Cambridge, Addenbrookes Hosp, Juvenile Diabet Res Fdn,Cambridge Inst Med Res, Wellcome Trust Diabet & Inflammat Lab, Cambridge CB2 0XY, England

[5] Dana Farber Canc Inst, CCSB, Boston, MA 02115 USA

[6] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA

[7] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[8] Yale Univ, Yale Syst Biol Inst, New Haven, CT 06520 USA

[9] Univ Copenhagen, Dept Biol, DK-2200 Copenhagen, Denmark

[10] BGI Shenzhen, Shenzhen 518083, Peoples R China

[11] Max Planck Inst Dev Biol, Dept Mol Biol, D-72076 Tubingen, Germany

[12] MIT, Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

来源：

NATURE REVIEWS GENETICS | 2010年 / 11卷 / 10期

基金：

英国惠康基金;

关键词：

RECENT POSITIVE SELECTION; EMBRYONIC STEM-CELLS; TRANSPOSABLE ELEMENTS; DRAFT SEQUENCE; COMPLEX TRAITS; ASSOCIATION; EVOLUTION; REVEALS; BIOLOGY; DIFFERENTIATION;

D O I：

10.1038/nrg2878

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

To celebrate the first 10 years of Nature Reviews Genetics, we asked eight leading researchers for their views on the key developments in genetics and genomics in the past decade and the prospects for the future. Their responses highlight the incredible changes that the field has seen, from the explosion of genomic data and the many possibilities it has opened up to the ability to reprogramme adult cells to pluripotency. The way ahead looks similarly exciting as we address questions such as how cells function as systems and how complex interactions among genetics, epigenetics and the environment combine to shape phenotypes.

引用

页码：723 / 733

页数：11

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