Psychological stress may induce diabetes-related autoimmunity in infancy

OBJECTIVE- in retrospective studies, a number of disparate environmental factors (including experiences of serious life events) have been proposed as trigger mechanisms for type 1 diabetes or the autoimmune process behind the disease. Psychosocial stress in families may affect children negatively due to a link to hormonal levels and nervous signals that in turn influence both insulin sensitivity/insulin need and the immune system. Our aim was to investigate whether psychological stress, measured as psychosocial strain in families, is associated with diabetes-related autoimmunity during infancy. RESEARCH DESIGN AND METHODS- The first 4,400 consecutive 1-year-old children from a large prospective population-based project Participated in the study. Parents completed questionnaires at birth and at 1 year, including various measures of psychosocial stress (e.g., parenting Stress) and sociodemographic background. Blood samples draw from the children at 1 year were analyzed for type 1 diabetes-associated autoantibodies toward tyrosine phosphatase and GAD. Antibodies toward tetanus toxoid were used as non-diabetes-related control antibodies. RESULTS- Psychosocial factors, i.e., high parenting stress (odds ratio 1.8 [95% Cl 1.2-2.9], P < 0.01), experiences of a serious life event (2.3 [1.3-4.0], P < 0.01), foreign origin of the mother (2.1 [1.3-3.3], P < 0.001), and low paternal education (1.6 [1.1-2.3], P < 0.01) were associated with diabctes-related autouninunity in the child, independent of family history of diabetes. CONCLUSIONS - Psychological stress, measured as psychosocial strain in the family, Seems to be involved in the induction, or progression, of diabetes-related autoimmunity in the child during the 1st year of life.