Lmx1b is essential for the development of serotonergic neurons

被引：204

作者：

Ding, YQ

Marklund, U

Yuan, WL

Yin, J

Wegman, L

Ericson, J

Deneris, E

Johnson, RL

Chen, ZF ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Pain Ctr, Dept Anesthesiol, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Pain Ctr, Dept Psychiat, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Pain Ctr, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA

[4] Karolinska Inst, Dept Cell & Mol Biol, S-17177 Stockholm, Sweden

[5] Case Western Reserve Univ, Sch Med, Dept Neurosci, Cleveland, OH 44106 USA

[6] Univ Texas, MD Anderson Canc Ctr, Dept Biochem & Mol Biol, Houston, TX 77030 USA

来源：

NATURE NEUROSCIENCE | 2003年 / 6卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nn1104

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The specification and differentiation of serotonergic (5-HT) neurons require both extrinsic signaling molecules and intrinsic transcription factors to work in concert or in cascade. Here we identify the genetic cascades that control the specification and differentiation of 5-HT neurons in mice. A major determinant in the cascades is an LIM homeodomain-containing gene, Lmx1b, which is required for the development of all 5-HT neurons in the central nervous system. Our results suggest that, during development of 5-HT neurons, Lmx1b is a critical intermediate factor that couples Nkx2-2-mediated early specification with Pet1-mediated terminal differentiation. Moreover, our data indicate that genetic cascades controlling the caudal and rostral 5-HT neurons are distinct, despite their shared components.

引用

页码：933 / 938

页数：6

共 28 条

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