Viscoelastic and mechanical behavior of recombinant protein elastomers

被引：114

作者：

Nagapudi, K

Brinkman, WT

Thomas, BS

Park, JO

Srinivasarao, M

Wright, E

Conticello, VP

Chaikof, EL

机构：

[1] Emory Univ, Dept Surg, Atlanta, GA 30322 USA

[2] Emory Univ, Dept Biomed Engn, Atlanta, GA 30322 USA

[3] Georgia Inst Technol, Sch Polymer Text & Fiber Engn, Atlanta, GA 30332 USA

[4] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA

[5] Emory Univ, Dept Chem, Atlanta, GA 30322 USA

[6] Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA

[7] Merck & Co Inc, Rahway, NJ 07095 USA

来源：

BIOMATERIALS | 2005年 / 26卷 / 23期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

recombinant protein; protein polymer; triblock copolymer; elastin-mimetic; mechanical behavior; viscoelastic properties;

D O I：

10.1016/j.biomaterials.2004.11.027

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Recombinant DNA synthesis was employed to produce elastin-mimetic protein triblock copolymers containing chemically distinct midblocks. These materials displayed a broad range of mechanical and viscoelastic responses ranging from plastic to elastic when examined as hydrated gels and films. These properties could be related in a predictable fashion to polymer block size and structure. While these materials could be easily processed into films and gels, electrospinning proved a feasible strategy for creating protein fibers. All told, the range of properties exhibited by this new class of protein triblock copolymer in combination with their easy processability suggests potential utility in a variety of soft prosthetic and tissue engineering applications. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：4695 / 4706

页数：12

共 30 条

[1]

Boey FYC, 2000, J APPL POLYM SCI, V76, P1248, DOI 10.1002/(SICI)1097-4628(20000523)76:8<1248::AID-APP5>3.0.CO

[2]

2-0

[3] In-situ self-assembling protein polymer gel systems for administration, delivery, and release of drugs [J].