Pan-PPAR Agonists Based on the Resveratrol Scaffold: Biological Evaluation and Docking Studies

被引：15

作者：

Li, Wei ^{[1
]}

He, Xinhua ^{[1
]}

Shi, Weiguo ^{[1
]}

Jia, Haoyan ^{[1
]}

Zhong, Bohua ^{[1
]}

机构：

[1] Beijing Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China

来源：

CHEMMEDCHEM | 2010年 / 5卷 / 12期

关键词：

metabolic diseases; molecular modeling; pan-PPAR agonists; receptors; resveratrol; CORONARY HEART-DISEASE; STRUCTURAL DETERMINANTS; ALPHA-ISOFORM; IN-VITRO; PROLIFERATOR; DISCOVERY; PTEROSTILBENE; DYSLIPIDEMIA; CHOLESTEROL; METABOLISM;

D O I：

10.1002/cmdc.201000360

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

[No abstract available]

引用

页码：1977 / 1982

页数：6

共 32 条

[1]

ARICHI H, 1982, CHEM PHARM BULL, V30, P1766

[2]

FENOFIBRATE - A REVIEW OF ITS PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES AND THERAPEUTIC USE IN DYSLIPIDEMIA [J].

BALFOUR, JA ;

MCTAVISH, D ;

HEEL, RC .

DRUGS, 1990, 40 (02) :260-290

[3]

Therapeutic potential of resveratrol:: the in vivo evidence [J].

Baur, Joseph A. ;

Sinclair, David A. .

NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (06) :493-506

[4]

Current, new and future treatments in dyslipidaemia and atherosclerosis [J].

Chong, PH ;

Bachenheimer, BS .

DRUGS, 2000, 60 (01) :55-93

[5]

AN ANTIPLATELET PRINCIPLE OF VERATRUM-FORMOSANUM [J].

CHUNG, MI ;

TENG, CM ;

CHENG, KL ;

KO, FN ;

LIN, CN .

PLANTA MEDICA, 1992, 58 (03) :274-276

[6]

CREASY LL, 1988, J AM SOC HORTIC SCI, V113, P230

[7]

INHIBITION OF HUMAN LDL OXIDATION BY RESVERATROL [J].

FRANKEL, EN ;

WATERHOUSE, AL ;

KINSELLA, JE .

LANCET, 1993, 341 (8852) :1103-1104

[8]

Role of peroxisome proliferator-activated receptor-α (PPARα) in bezafibrate-induced hepatocarcinogenesis and cholestasis [J].

Hays, T ;

Rusyn, I ;

Burns, AM ;

Kennett, MJ ;

Ward, JM ;

Gonzalez, FJ ;

Peters, JM .

CARCINOGENESIS, 2005, 26 (01) :219-227

[9]

DIET, ALCOHOL AND CORONARY HEART-DISEASE IN MEN [J].

HEGSTED, DM ;

AUSMAN, LM .

JOURNAL OF NUTRITION, 1988, 118 (10) :1184-1189

[10]

INAMORI Y, 1987, CHEM PHARM BULL, V35, P887

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