Microfluidic gradient platforms for controlling cellular behavior

被引：79

作者：

Chung, Bong Geun ^{[1
]}

Choo, Jaebum ^{[1
]}

机构：

[1] Hanyang Univ, Dept Bionano Engn, Ansan 436791, South Korea

来源：

ELECTROPHORESIS | 2010年 / 31卷 / 18期

关键词：

Axon guidance; Chemotaxis; Gradient; Microfluidics; Stem cell differentiation; EMBRYONIC STEM-CELLS; NERVE GROWTH-FACTOR; BACTERIAL CHEMOTAXIS; CANCER-CELLS; NEUTROPHIL CHEMOTAXIS; QUANTITATIVE-ANALYSIS; MORPHOGEN GRADIENT; CHEMICAL GRADIENTS; AXON REGENERATION; CULTURE-SYSTEMS;

D O I：

10.1002/elps.201000137

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Concentration gradients play an important role in controlling biological and pathological processes, such as metastasis, embryogenesis, axon guidance, and wound healing. Microfluidic devices fabricated by photo- and soft lithography techniques can manipulate the fluidic flow and diffusion profile to create biomolecular gradients in a temporal and spatial manner. Furthermore, microfluidic devices enable the control of cell-extracellular microenvironment interactions, including cell cell, cell matrix, and cell soluble factor interaction. In this paper, we review the development of microfluidic-based gradient devices and highlight their biological applications.

引用

页码：3014 / 3027

页数：14

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