Focal cerebral perfusion defects demonstrated by Tc-99m-hexamethylpropyleneamine oxime SPECT in elderly depressed patients

被引：26

作者：

Vasile, RG ^{[1
]}

Schwartz, RB ^{[1
]}

Garada, B ^{[1
]}

Holman, BL ^{[1
]}

Alpert, M ^{[1
]}

Davidson, PB ^{[1
]}

Schildkraut, JJ ^{[1
]}

机构：

[1] HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT RADIOL,BOSTON,MA 02115

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 1996年 / 67卷 / 01期

关键词：

single photon emission computed tomography; affective disorder; aging; geriatric psychiatry; frontal lobe;

D O I：

10.1016/0925-4927(96)02689-3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

High resolution single photon emission computed tomography (SPECT) was used to evaluate regional cerebral blood flow (rCBF) in 14 acutely depressed elderly patients and 29 normal subjects. SPECT images of the two groups were randomized and blindly read. Foci of decreased radionuclide uptake were assessed by number and location. The total number of rCBF defects per whole brain study was significantly greater in the depressed patients than in the normal subjects. A significantly greater number of rCBF defects was found most strikingly in the lateral frontal and less prominently in the lateral and medial temporal brain regions of the depressed patients.

引用

页码：59 / 70

页数：12

共 45 条

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