Monitoring the duration of antigen-receptor occupancy by calcineurin/glycogen-synthase-kinase-3 control of NF-AT nuclear shuttling

被引：33

作者：

Neilson, J

Stankunas, K

Crabtree, GR

机构：

[1] Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Dev Biol, Stanford, CA 94305 USA

[3] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2001年 / 13卷 / 03期

关键词：

D O I：

10.1016/S0952-7915(00)00225-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent structural studies have supported a kinetic model of TCR activation, raising the question of how the duration of receptor occupancy is translated into activation of immune response genes. We summarize evidence that the cytoplasmic-to-nuclear shuttling of NF-ATc family members monitors the duration of receptor occupancy.

引用

页码：346 / 350

页数：5

共 44 条

[1] Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A
Aramburu, J
Yaffe, MB
López-Rodríguez, C
Cantley, LC
Hogan, PG
Rao, A
[J]. SCIENCE, 1999, 285 (5436) : 2129 - 2133
[2] Cyclosporine inhibition of leukocyte calcineurin is much less in whole blood than in culture medium
Batiuk, TD
Pazderka, F
Enns, J
DeCastro, L
Halloran, PF
[J]. TRANSPLANTATION, 1996, 61 (01) : 158 - 161
[3] CALCINEURIN ACTIVITY IS ONLY PARTIALLY INHIBITED IN LEUKOCYTES OF CYCLOSPORINE-TREATED PATIENTS
BATIUK, TD
PAZDERKA, F
HALLORAN, PF
[J]. TRANSPLANTATION, 1995, 59 (10) : 1400 - 1404
[4] CYCLOSPORINE INHIBITION OF CALCINEURIN ACTIVITY IN HUMAN-LEUKOCYTES IN-VIVO IS RAPIDLY REVERSIBLE
BATIUK, TD
PAZDERKA, F
ENNS, J
DECASTRO, L
HALLORAN, PF
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (03) : 1254 - 1260
[5] Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3
Beals, CR
Sheridan, CM
Turck, CW
Gardner, P
Crabtree, GR
[J]. SCIENCE, 1997, 275 (5308) : 1930 - 1933
[6] Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction
Beals, CR
Clipstone, NA
Ho, SN
Crabtree, GR
[J]. GENES & DEVELOPMENT, 1997, 11 (07) : 824 - 834
[7] Jun N-terminal kinase 2 modulates thymocyte apoptosis and T cell activation through c-Jun and nuclear factor of activated T cell (NF-AT)
Behrens, A
Sabapathy, K
Graef, I
Cleary, M
Crabtree, GR
Wagner, EF
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (04) : 1769 - 1774
[8] THE ZETA-CHAIN IS ASSOCIATED WITH A TYROSINE KINASE AND UPON T-CELL ANTIGEN RECEPTOR STIMULATION ASSOCIATES WITH ZAP-70, A 70-KDA TYROSINE PHOSPHOPROTEIN
CHAN, AC
IRVING, BA
FRASER, JD
WEISS, A
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (20) : 9166 - 9170
[9] c-Jun NH2-terminal kinase inhibits targeting of the protein phosphatase calcineurin to NFATc1
Chow, CW
Dong, C
Flavell, RA
Davis, RJ
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (14) : 5227 - 5234
[10] Chow CW, 1999, MOL CELL BIOL, V19, P2300

← 1 2 3 4 5 →