Dibefurin, a novel fungal metabolite inhibiting calcineurin phosphatase activity

被引：11

作者：

Brill, GM

Premachandran, U

Karwowski, JP

Henry, R

Cwik, DK

Traphagen, LM

Humphrey, PE

Jackson, M

Clement, JJ

Burres, NS

Kadam, S

Chen, RH

McAlpine, JB

机构：

[1] New Lead Discovery, Pharmaceutical Prod. R. and D., Abbott Laboratories, Abbott Park

来源：

JOURNAL OF ANTIBIOTICS | 1996年 / 49卷 / 02期

关键词：

LYMPHOCYTE;

D O I：

10.7164/antibiotics.49.124

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The novel calcineurin inhibitor, dibefurin, has been isolated from the fungal culture AB 1650I-759. The isolation was bioactivity-directed fractionation using an assay which measures the phosphatase activity of calcineurin. The compound was purified by countercurrent, reverse phase and gel filtration chromatographies. Several studies, including crystallographic, NMR and MS, revealed that dibefurin is a novel dimeric compound of a unique structural type.

引用

页码：124 / 128

页数：5

共 9 条

[1] SIMPLE AROMATICS IDENTIFIED WITH A NFAT-LACZ TRANSCRIPTION ASSAY FOR THE DETECTION OF IMMUNOSUPPRESSANTS
BURRES, NS
PREMACHANDRAN, U
HOSELTON, S
CWIK, D
HOCHLOWSKI, JE
YE, QM
SUNGA, GN
KARWOWSKI, JP
JACKSON, M
WHITTERN, DN
MCALPINE, JB
[J]. JOURNAL OF ANTIBIOTICS, 1995, 48 (05) : 380 - 386
[2] IDENTIFICATION OF CALCINEURIN AS A KEY SIGNALING ENZYME IN LYMPHOCYTE-T ACTIVATION
CLIPSTONE, NA
CRABTREE, GR
[J]. NATURE, 1992, 357 (6380) : 695 - 697
[3] CLIPSTONE NA, 1993, ANN NY ACAD SCI, V696, P20
[4] ASPERLICIN, A NOVEL NON-PEPTIDAL CHOLECYSTOKININ ANTAGONIST FROM ASPERGILLUS-ALLIACEUS - FERMENTATION, ISOLATION AND BIOLOGICAL PROPERTIES
GOETZ, MA
LOPEZ, M
MONAGHAN, RL
CHANG, RSL
LOTTI, VJ
CHEN, TB
[J]. JOURNAL OF ANTIBIOTICS, 1985, 38 (12) : 1633 - 1637
[5] ASELACINS, NOVEL COMPOUNDS THAT INHIBIT BINDING OF ENDOTHELIN TO ITS RECEPTOR .1. THE PRODUCING ORGANISM, FERMENTATION AND BIOLOGICAL-ACTIVITY
JACKSON, M
BURRES, NS
KARWOWSKI, JP
ALDER, LA
HUMPHREY, PE
KOHL, WL
MCALPINE, JB
[J]. JOURNAL OF ANTIBIOTICS, 1994, 47 (05) : 523 - 527
[6] MLR-52, (4'-DEMETHYLAMINO-4',5'-DIHYDROXYSTAUROSPORINE), A NEW INHIBITOR OF PROTEIN-KINASE-C WITH IMMUNOSUPPRESSIVE ACTIVITY
MCALPINE, JB
KARWOWSKI, JP
JACKSON, M
MULLALLY, MM
HOCHLOWSKI, JE
PREMACHANDRAN, U
BURRES, NS
[J]. JOURNAL OF ANTIBIOTICS, 1994, 47 (03) : 281 - 288
[7] MILLER MW, 1961, PFIZER HDB MICROBIAL, P185
[8] STUDIES IN THE BIOCHEMISTRY OF MICRO-ORGANISMS .97. FLAVIPIN, A CRYSTALLINE METABOLITE OF ASPERGILLUS-FLAVIPES (BAINIER AND SARTORY) THOM AND CHURCH AND ASPERGILLUS-TERREUS THOM
RAISTRICK, H
RUDMAN, P
[J]. BIOCHEMICAL JOURNAL, 1956, 63 (03) : 395 - 406
[9] OBSERVATIONS ON THE MECHANISM OF ACTION OF FK-506 - A PHARMACOLOGICAL PROBE OF LYMPHOCYTE SIGNAL TRANSDUCTION
SIGAL, NH
SIEKIERKA, JJ
DUMONT, FJ
[J]. BIOCHEMICAL PHARMACOLOGY, 1990, 40 (10) : 2201 - 2208

← 1 →