Comparison of Interleukin-6 Removal Properties among Hemofilters Consisting of Varying Membrane Materials and Surface Areas: An in vitro Study

被引：25

作者：

Hirayama, Yo ^{[1
,2
]}

Oda, Shigeto ^{[2
]}

Wakabayashi, Kiyohito ^{[3
]}

Sadahiro, Tomohito ^{[2
]}

Nakamura, Masataka ^{[2
]}

Watanabe, Eizo ^{[2
]}

Tateishi, Yoshihisa ^{[2
]}

机构：

[1] Chiba Univ, Grad Sch Med, Dept Blood Purificat, Chuo Ku, Chiba 2608677, Japan

[2] Chiba Univ, Dept Emergency & Crit Care Med, Chiba 2608677, Japan

[3] Chiba Univ, Dept Nephrol, Chiba 2608677, Japan

来源：

BLOOD PURIFICATION | 2011年 / 31卷 / 1-3期

关键词：

Continuous hemodiafiltration; Hypercytokinemia; Polymethyl methacrylate; Cytokine-adsorbing hemofilter; Interleukin-6; CONTINUOUS VENOVENOUS HEMOFILTRATION; HIGH-VOLUME HEMOFILTRATION; INFLAMMATORY RESPONSE SYNDROME; SEPTIC SHOCK; BLOOD PURIFICATION; CYTOKINE REMOVAL; CRITICAL-CARE; SEPSIS; ADSORPTION; HYPERCYTOKINEMIA;

D O I：

10.1159/000321142

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Background/Aims: We sought to identify the most relevant hemofilter for cytokine removal based on the mechanisms of filtration and adsorption. Methods: Ascites were filtered using four types of hemofilters composed of different membrane materials (polymethyl methacrylate, PMMA, cellulose triacetate, CTA, or polysulfone, PS) and different surface areas (1.0 or 2.1 m(2)) to investigate the rate of interleukin-6 (IL-6) filtration. Next, ascites were perfused through each hemofilter without obtaining a filtrate to study each filter's adsorptive capability. Results: The PMMA hemofilters resulted in a marginal observed IL-6 filtration rates, whereas the CTA and PS hemofilters resulted in highly effective IL-6 filtration. Regarding the IL-6 adsorptive capabilities of the filters, the PMMA hemofilter with a large surface area showed the highest level of IL-6 clearance. Conclusion: The present findings suggest that when cytokine removal based on filtration is desired, CTA or PS hemofilters should be selected. When IL-6 removal based on adsorption is desired, a PMMA hemofilter with a large surface area should be selected. Copyright (C) 2010 S. Karger AG, Basel

引用

页码：18 / 25

页数：8

共 21 条

[1]

CONTINUOUS VENOVENOUS HEMOFILTRATION WITH DIALYSIS REMOVES CYTOKINES FROM THE CIRCULATION OF SEPTIC PATIENTS [J].