Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives

被引：231

作者：

Fredriksson, R ^{[1
]}

Höglund, PJ ^{[1
]}

Gloriam, DEI ^{[1
]}

Lagerström, MC ^{[1
]}

Schiöth, HB ^{[1
]}

机构：

[1] Uppsala Univ, Dept Neurosci, BMC, S-75124 Uppsala, Sweden

来源：

FEBS LETTERS | 2003年 / 554卷 / 03期

关键词：

orphan; human genome; rhodopsin; G protein-coupled receptor; evolution;

D O I：

10.1016/S0014-5793(03)01196-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report seven new members of the superfamily of human G protein-coupled receptors (GPCRs) found by searches in the human genome databases, termed GPR100, GPR119, GPR120, GPR135, GPR136, GPR141, and GPR142. We also report 16 orthologues of these receptors in mouse, rat, fugu (pufferfish) and zebrafish. Phylogenetic analysis shows that these are additional members of the family of rhodopsin-type GPCRs. GPR100 shows similarity with the orphan receptor SALPR. Remarkably, the other receptors do not have any close relative among other known human rhodopsin-like GPCRs. Most of these orphan receptors are highly conserved through several vertebrate species and are present in single copies. Analysis of expressed sequence tag (EST) sequences indicated individual expression patterns, such as for GPR135, which was found in a wide variety of tissues including eye, brain, cervix, stomach and testis. Several ESTs for GPR141 were found in marrow and cancer cells, while the other receptors seem to have more restricted expression patterns. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：381 / 388

页数：8

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