Neuropeptide gene polymorphisms and human behavioural disorders

被引：17

作者：

Inui, A ^{[1
]}

机构：

[1] Kobe Univ, Grad Sch Med, Dept Clin Mol Med, Div Diabet Digest & Kidney Dis,Chuo Ku, Kobe, Hyogo 6500017, Japan

来源：

NATURE REVIEWS DRUG DISCOVERY | 2003年 / 2卷 / 12期

关键词：

D O I：

10.1038/nrd1252

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Energy homeostasis is controlled by a complex neuroendocrine system consisting of peripheral signals, such as leptin, and central signals, particularly neuropeptides. Animal experiments have demonstrated that neuropeptides present in the hypothalamus and other brain areas are important not only in the regulation of feeding and metabolism, but also in other neuroendocrine and behavioural functions. Knowledge about neuropeptides is increasingly used in the study of the pathophysiology of behavioural disorders. This review focuses on the influence of polymorphisms in genes encoding neuropeptides or neuropeptide receptors involved in diverse physiological processes. The identification of neuropeptide systems closely associated with human illnesses will aid the development of novel therapeutic strategies.

引用

收藏

页码：986 / 998

页数：13

相关论文

共 165 条

[1] Drug target discovery by pharmacogenetics: mutations in the melanocortin system and eating disorders [J].

Adan, RAH ;

Vink, T .

EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2001, 11 (06) :483-490

[2] A polymorphism in the human agouti-related protein is associated with late-onset obesity [J].

Argyropoulos, G ;

Rankinen, T ;

Neufeld, DR ;

Rice, T ;

Province, MA ;

Leon, AS ;

Skinner, JS ;

Wilmore, JH ;

Rao, DC ;

Bouchard, C .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (09) :4198-4202

[3]

Baerwald CGO, 1997, J RHEUMATOL, V24, P215

[4] INTERACTION OF ENDOTHELIN-3 WITH ENDOTHELIN-B RECEPTOR IS ESSENTIAL FOR DEVELOPMENT OF EPIDERMAL MELANOCYTES AND ENTERIC NEURONS [J].

BAYNASH, AG ;

HOSODA, K ;

GIAID, A ;

RICHARDSON, JA ;

EMOTO, N ;

HAMMER, RE ;

YANAGISAWA, M .

CELL, 1994, 79 (07) :1277-1285

[5] A single nucleotide polymorphic mutation in the human μ-opioid receptor severely impairs receptor signaling [J].

Befort, K ;

Filliol, D ;

Décaillot, FM ;

Gavériaux-Ruff, C ;

Hoehe, MR ;

Kieffer, BL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (05) :3130-3137

[6] mu opioid receptor gene variants: lack of association with alcohol dependence [J].

Bergen, AW ;

Peterson, R ;

Kokoszka, J ;

Long, JC ;

Virkkunen, M ;

Linnoila, M ;

Goldman, D .

MOLECULAR PSYCHIATRY, 1997, 2 (06) :490-494

[7] Human mu opioid receptor gene polymorphisms and vulnerability to substance abuse [J].

Berrettini, WH ;

Hoehe, MR ;

Ferraro, TN ;

DeMaria, PA ;

Gottheil, E .

ADDICTION BIOLOGY, 1997, 2 (03) :303-308

[8] Novel neuropeptide Y1 and Y5 receptor gene variants: associations with serum triglyceride and high-density lipoprotein cholesterol levels [J].

Blumenthal, JB ;

Andersen, RE ;

Mitchell, BD ;

Seibert, MJ ;

Yang, H ;

Herzog, H ;

Beamer, BA ;

Franckowiak, SC ;

Walston, JD .

CLINICAL GENETICS, 2002, 62 (03) :196-202

[9] Single-nucleotide polymorphism in the human mu opioid receptor gene alters β-endorphin binding and activity:: Possible implications for opiate addiction [J].

Bond, C ;

LaForge, KS ;

Tian, MT ;

Melia, D ;

Zhang, SW ;

Borg, L ;

Gong, JH ;

Schluger, J ;

Strong, JA ;

Leal, SM ;

Tischfield, JA ;

Kreek, MJ ;

Yu, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (16) :9608-9613

[10] Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease [J].

Botstein, D ;

Risch, N .

NATURE GENETICS, 2003, 33 (Suppl 3) :228-237

← 1 2 3 4 5 6 7 8 9 10 →