Growth inhibitory factor and zinc affect neural cell cultures in a tissue specific manner

被引：12

作者：

Bruinink, A

Faller, P

Sidler, C

Bogumil, R

Vasák, M

机构：

[1] Swiss Fed Inst Technol, Inst Toxicol, CH-8603 Schwerzenbach, Switzerland

[2] Univ Zurich, Inst Biochem, CH-8057 Zurich, Switzerland

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 1998年 / 115卷 / 03期

关键词：

GIF; metallothionein; Alzheimer's disease; zinc; brain; neural retina culture;

D O I：

10.1016/S0009-2797(98)00062-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Deficiency of neuronal growth inhibitory factor (GIF) and abnormalities in zinc homeostasis have been suggested to play a role in the neuropathogenesis of Alzheimer's disease. We report here that embryonic chick cerebral cell cultures zinc and copper containing GIF in the presence of marmoset hippocampal extract reduces significantly and concentration dependently mitochondrial succinate dehydrogenase activity (MTT) and cell mass. In contrast, no indications could be found that GIF; affected neural retina cell cultures. Our results suggest that the observed effects of GIF are not elicited by zinc. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：167 / 174

页数：8

共 24 条

[1] Evidence for Cu(I) clusters and Zn(II) clusters in neuronal growth-inhibitory factor isolated from bovine brain [J].