Polyendocrinopathy in Children, Adolescents, and Young Adults With Type 1 Diabetes A multicenter analysis of 28,671 patients from the German/Austrian DPV-Wiss database

被引:77
作者
Warncke, Katharina [1 ]
Froehlich-Reiterer, Elke E. [2 ]
Thon, Angelika [3 ]
Hofer, Sabine E. [4 ]
Wiemann, Dagobert [5 ]
Holl, Reinhard W. [6 ]
机构
[1] Tech Univ Munich, Dept Pediat, Munich, Germany
[2] Med Univ Graz, Dept Pediat, Graz, Austria
[3] Hannover Med Sch, Dept Pediat, D-3000 Hannover, Germany
[4] Med Univ Innsbruck, Dept Pediat, Innsbruck, Austria
[5] Otto VonGuericke Univ Magdegurg, Dept Pediat, D-39016 Magdeburg, Germany
[6] Univ Ulm, Dept Epidemiol, Ulm, Germany
关键词
CELIAC-DISEASE; THYROID AUTOIMMUNITY; AUTOANTIBODIES; FREQUENCY; MELLITUS; ONSET; AGE;
D O I
10.2337/dc10-0404
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
OBJECTIVE - To investigate diabetes-specific autoantibodies and additional autoimmune phenomena in a large cohort of young patients with type 1 diabetes. RESEARCH DESIGN AND METHODS - Data from 28,671 patients <30 years with type 1 diabetes from 242 specialized centers in Germany and Austria were analyzed. RESULTS - At least one beta-cell antibody was present in 81.6% of patients. beta-cell Ab-negative patients were significantly younger at diabetes onset (P < 0.0001). A total of 19.6% had positive thyroid antibodies with female predominance (62%, P < 0.0001). Antibodies to tissue transglutaminase were present in 10.7%, with a significantly longer duration of diabetes (P < 0.0001). Parietal cell antibodies were found in 283 patients, associated with older age (P < 0.001), and adrenal antibodies were present in 94 patients. In 575 patients, at least three different autoimmune phenomena were present. CONCLUSIONS - Thyroid autoimmunity and antibodies suggestive for celiac disease are the most prevalent additional immune phenomena in type 1 diabetes. Parietal/adrenal antibodies are rare.
引用
收藏
页码:2010 / 2012
页数:3
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