Understanding the benign nature of SIV infection in natural hosts

被引:164
作者
Silvestri, Guido
Paiardini, Mirko
Pandrea, Ivona
Lederman, Michael M.
Sodora, Donald L.
机构
[1] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
[2] Emory Univ, Yerkes Reg Primate Res Ctr, Atlanta, GA 30322 USA
[3] Tulane Univ, Tulane Hlth Sci Ctr, Tulane Natl Primate Res Ctr, Covington, LA USA
[4] Case Western Reserve Univ, Dept Med, Cleveland, OH 44106 USA
[5] Univ Texas, SW Med Ctr, Dept Med, Dallas, TX USA
关键词
D O I
10.1172/JCI33034
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
In striking contrast to HIV infection, natural SIV infection of African nonhuman primates is asymptomatic and usually does not induce significant CD4(+) T cell depletion despite high levels of virus replication. Recently, significant progress has been made in understanding the mechanisms underlying the remarkable difference in infection outcome between natural and nonnatural HIV/SIV hosts. These advances include the identification of limited immune activation as a key factor protecting, natural SIV hosts from AIDS and the discovery of low CC chemokine receptor 5 expression on CD4(+) T cells as a specific and consistent immunologic feature in these animals. Further elucidation of the pathways by which the differences in immune activation between natural and nonnatural hosts are manifest holds promise for the design of novel therapeutic approaches to HIV infection.
引用
收藏
页码:3148 / 3154
页数:7
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