Effects of acute olanzapine after sustained fluoxetine on extracellular monoamine levels in the rat medial prefrontal cortex

被引：25

作者：

Amargós-Bosch, M ^{[1
]}

Artigas, F ^{[1
]}

Adell, A ^{[1
]}

机构：

[1] CSIC, Inst Invest Biomed Barcelona, Dept Neurochem, IDIBAPS, E-08036 Barcelona, Spain

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2005年 / 516卷 / 03期

关键词：

medial prefrontal cortex; fluoxetine; olanzapine; microdialysis; osmotic minipump;

D O I：

10.1016/j.ejphar.2005.05.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The combination of selective serotonin reuptake inhibitors with atypical antipsychotic drugs exhibits beneficial effects in treatment-resistant depression. We investigated the effects of a 2-week treatment with a low fluoxetine dose (3 mg/kg per day) plus a single injection of olanzapine (3 mg/kg) on the dialysate concentration of noradrenaline, dopamine and serotonin (5-HT) in the medial prefrontal cortex of the rat. Chronic fluoxetine increased only 5-HT levels whereas single olanzapine administration increased the concentration of catecholamines and decreased that of 5-HT to a comparable extent in vehicle- and fluoxetine-treated rats. Therefore, it is possible that the therapeutic benefit of this pharmacological combination may not be associated to changes in the cortical concentration of monoamines, but to postsynaptic blockade of monoaminergic receptors. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：235 / 238

页数：4

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