Evaluation of laser Doppler imaging to measure blood flow in knee ligaments of adult rabbits

被引：29

作者：

Bray, R ^{[1
]}

Forrester, K ^{[1
]}

McDougall, JJ ^{[1
]}

Damji, A ^{[1
]}

Ferrell, WR ^{[1
]}

机构：

[1] UNIV GLASGOW,DIV NEUROSCI & BIOMED SYST,INST BIOMED & LIFE SCI,GLASGOW G12 8QQ,LANARK,SCOTLAND

来源：

MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING | 1996年 / 34卷 / 03期

关键词：

blood flow; healing; injury; laser Doppler; ligament; rabbits;

D O I：

10.1007/BF02520078

中图分类号：

TP39 [计算机的应用];

学科分类号：

081203 ; 0835 ;

摘要：

Laser Doppler imaging (LDI) is investigated as a novel method for in vivo ligament tissue blood flow determination. LDI output signal is obtained from surgically exposed rabbit medial collateral ligaments (MCL). The LDI signal is compared with simultaneously determined, coloured microsphere (CM)-derived standardised MCL blood flow. Correlation of LDI output with the CM flow data and a linear regression of 17 data points in nine rabbits (joint injured to provoke an acute vascular response in the tissues) indicate that LDI provides a reasonable estimate of MCL blood flow, at least over the ranges assessed. If properly calibrated, and given enough tissue-specific data points, LDI may have advantages over conventional, but more invasive, techniques. The potential clinical application of LDI technology to joint injury and arthritis research is discussed.

引用

页码：227 / 231

页数：5

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