Factors associated with poor health-related quality of life of patients with cirrhosis

被引:406
作者
Marchesini, G
Bianchi, G
Amodio, P
Salerno, F
Merli, M
Panella, C
Loguercio, C
Apolone, G
Niero, M
Abbiati, R
机构
[1] Univ Bologna, Dipartimento Med Interna, Policlin S Orsola, I-40138 Bologna, Italy
[2] Univ Padua, Padua, Italy
[3] Univ Milan, Milan, Italy
[4] Univ Rome, Rome, Italy
[5] Univ Bari, Bari, Italy
[6] Univ Naples, Naples, Italy
[7] Univ Verona, I-37100 Verona, Italy
[8] Ist Ric Farmacol Mario Negri, Milan, Italy
[9] Bracco Ind Chim Spa, Direz Med Italia, Milan, Italy
关键词
D O I
10.1053/gast.2001.21193
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background & Aims: Increasing interest is being given to health-related quality of life in chronic diseases, In cirrhosis, both physical functioning and mental well-being may be altered, but no study has investigated factors associated with a poor perceived health status, Methods: We measured quality of life by Short Form-36 and Nottingham Health Profile questionnaires in 544 patients with cirrhosis. Data were compared with age- and gender-adjusted values of 2 random samples of the Italian population (more than 2000 subjects). Factors associated with poor perceived health status were identified by logistic regression, Results: All domains of health-related quality of life, except pain, were altered in cirrhosis (by 9%-42%), mainly in younger patients. There were minor differences in relation to gender, whereas etiology had no effects. Severity of disease (Child-Pugh score) and, above all, muscle cramps were the factors most closely associated with poor health status perception, Self-rating of disease progression was associated with ascites and pruritus, whereas previous variceal sclerotherapy and the use of disaccharides had a protective effect. Most areas of daily life were affected by perceived health problems; this was mainly true for paid employment and sex life in men and home life and social life in women. Conclusions: Quality of life is variably impaired in cirrhosis, also in uncomplicated patients. Non-life-threatening symptoms, such as muscle cramps, are of major concern, These data are the basis for longitudinal studies measuring the effects of therapy and procedures on patient-derived health outcomes.
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页码:170 / 178
页数:9
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