FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body

被引：24

作者：

Harris, MJ ^{[1
]}

Arias, IM ^{[1
]}

机构：

[1] Tufts Univ, Sch Med, Dept Physiol, Boston, MA 02111 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2003年 / 1633卷 / 02期

关键词：

aminophospholipid translocase; PFICI; BRIC; phospholipid; expression array;

D O I：

10.1016/S1388-1981(03)00107-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

ATP8B1/FIC1 is a member of the Type IV P-type ATPase family, which function as ATP dependent aminophospholipid translocases (APLT). We identified two familial intrahepatic cholestasis type I (FIC1) homologues, ATP8B2 and ATP8B3, with 53% and 45% amino acid identity, respectively. The expression profile for each gene was determined using a 73-tissue human RNA expression array. The subfamily of FIC1-like proteins is expressed in a wide range of tissues. Given that mutations in FIC1 result in liver disease, these proteins may have important roles in other organs in which they are candidates for genetic and acquired diseases. (C) 2003 Published by Elsevier B.V.

引用

页码：127 / 131

页数：5

共 18 条

[1]

Evolution of substrate specificities in the P-type ATPase superfamily [J].

Axelsen, KB ;

Palmgren, MG .

JOURNAL OF MOLECULAR EVOLUTION, 1998, 46 (01) :84-101

[2]

A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis [J].

Bull, LN ;

van Eijk, MJT ;

Pawlikowska, L ;

DeYoung, JA ;

Juijn, JA ;

Liao, M ;

Klomp, LWJ ;

Lomri, N ;

Berger, R ;

Scharschmidt, BF ;

Knisely, AS ;

Houwen, RHJ ;

Freimer, NB .

NATURE GENETICS, 1998, 18 (03) :219-224

[3]

Identification and functional expression of four isoforms of ATPase II, the putative aminophospholipid translocase - Effect of isoform variation on the ATPase activity and phospholipid specificity [J].

Ding, JT ;

Wu, Z ;

Crider, BP ;

Ma, YM ;

Li, XJ ;

Slaughter, C ;

Gong, LM ;

Xie, XS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (30) :23378-23386

[4]

FADOK VA, 1992, J IMMUNOL, V148, P2207

[5]

Chilling tolerance in arabidopsis involves ALA1, a member of a new family of putative aminophospholipid translocases [J].

Gomès, E ;

Jakobsen, MK ;

Axelsen, KB ;

Geisler, M ;

Palmgren, MG .

PLANT CELL, 2000, 12 (12) :2441-2453

[6]

Differential expression of putative transbilayer amphipath transporters [J].

Halleck, MS ;

Lawler, JF ;

Blackshaw, S ;

Gao, L ;

Nagarajan, P ;

Hacker, C ;

Pyle, S ;

Newman, JT ;

Nakanishi, Y ;

Ando, H ;

Weinstock, D ;

Williamson, P ;

Schlegel, RA .

PHYSIOLOGICAL GENOMICS, 1999, 1 (03) :139-150

[7]

Harris MJ, 2001, HEPATOLOGY, V34, p240A

[8]

An essential subfamily of Drs2p-related P-type ATPases is required for protein trafficking between Golgi complex and endosomal/vacuolar system [J].

Hua, ZL ;

Fatheddin, P ;

Graham, TR .

MOLECULAR BIOLOGY OF THE CELL, 2002, 13 (09) :3162-3177

[9]

Rapid transbilayer movement of fluorescent phospholipid analogues in the plasma membrane of endocytosis-deficient yeast cells does not require the Drs2 protein [J].

Marx, U ;

Polakowski, T ;

Pomorski, T ;

Lang, C ;

Nelson, H ;

Nelson, N ;

Herrmann, A .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1999, 263 (01) :254-263

[10]

Pomorski, T ;

Lombardi, R ;

Riezman, H ;

Devaux, PF ;

van Meer, G ;

Holthuis, JCM .

MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (03) :1240-1254

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